Galectin-3 in cardiovascular diseases

V Blanda, UM Bracale, MD Di Taranto… - International journal of …, 2020 - mdpi.com
Galectin-3 (Gal-3) is a β-galactoside-binding protein belonging to the lectin family with
pleiotropic regulatory activities and several physiological cellular functions, such as cellular …

[HTML][HTML] The therapeutic potential of galectin-3 inhibition in fibrotic disease

RJ Slack, R Mills, AC Mackinnon - … Journal of Biochemistry & Cell Biology, 2021 - Elsevier
Galectin-3 is a beta-galactoside-binding mammalian lectin and part of the 15 member
galectin family that are evolutionarily highly conserved. It is the only chimeric protein with a …

Galectin-3 as a next-generation biomarker for detecting early stage of various diseases

A Hara, M Niwa, K Noguchi, T Kanayama, A Niwa… - Biomolecules, 2020 - mdpi.com
Galectin-3 is a β-galactoside-binding lectin which is important in numerous biological
activities in various organs, including cell proliferation, apoptotic regulation, inflammation …

Cardiovascular biomarkers: lessons of the past and prospects for the future

F Omran, I Kyrou, F Osman, VG Lim… - International Journal of …, 2022 - mdpi.com
Cardiovascular diseases (CVDs) are a major healthcare burden on the population
worldwide. Early detection of this disease is important in prevention and treatment to …

The diagnostic and therapeutic potential of galectin-3 in cardiovascular diseases

G Sygitowicz, A Maciejak-Jastrzębska, D Sitkiewicz - Biomolecules, 2021 - mdpi.com
Galectin-3 plays a prominent role in chronic inflammation and has been implicated in the
development of many disease conditions, including heart disease. Galectin-3, a regulatory …

The role of galectin-3 in heart failure—the diagnostic, prognostic and therapeutic potential—where do we stand?

B Zaborska, M Sikora-Frąc, K Smarż… - International Journal of …, 2023 - mdpi.com
Heart failure (HF) is a clinical syndrome with high morbidity and mortality, and its prevalence
is rapidly increasing. Galectin-3 (Gal-3) is an important factor in the pathophysiology of HF …

Pathophysiology and clinical relevance of atrial myopathy

MRL Tubeeckx, GW De Keulenaer… - Basic Research in …, 2024 - Springer
Atrial myopathy is a condition that consists of electrical, structural, contractile, and autonomic
remodeling of the atria and is the substrate for development of atrial fibrillation, the most …

Clinical phenotypes and atrial fibrillation recurrences after catheter ablation: an unsupervised cluster analysis

A Bisson, AM Fawzy, W El-Bouri, D Angoulvant… - Current problems in …, 2023 - Elsevier
Catheter ablation (CA) is a well-established treatment of atrial fibrillation (AF). Data-driven
cluster analysis is able to better distinguish prognostically-relevant phenotype clusters …

Galectin-3 induces atrial fibrosis by activating the TGF-β1/Smad pathway in patients with atrial fibrillation

M Xiao, M Zhang, M Bie, X Wang, J Guo, H Xiao - Cardiology, 2020 - karger.com
Background: Atrial fibrosis plays a critical role in the occurrence and maintenance of atrial
fibrillation. The role of TGF-β1 in mediating atrial fibrosis is well documented. The β …

[HTML][HTML] Biomarkers in the clinical management of patients with atrial fibrillation and heart failure

I Koniari, E Artopoulou, D Velissaris… - Journal of Geriatric …, 2021 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) and heart failure (HF) are two cardiovascular diseases with an
increasing prevalence worldwide. These conditions share common pathophysiologiesand …