Tissue clearing of gross anatomical samples was first described more than a century ago
and has only recently found widespread use in the field of microscopy. This renaissance has …

Tissue clearing and light-sheet microscopy have a 100-year-plus history, yet these fields
have been combined only recently to facilitate novel experiments and measurements in …

Cytokine production by B cells is important for multiple aspects of immunity. B cell-derived
cytokines, including lymphotoxin, are essential for the ontogenesis, homeostasis and …

High endothelial venules (HEVs) are specialized blood vessels mediating lymphocyte
trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high …

Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that reflect lymphoid
neogenesis occurring in tissues at sites of inflammation. They are detected in tumors where …

Blood vascular endothelial cells (BECs) control the immune response by regulating blood
flow and immune cell recruitment in lymphoid tissues. However, the diversity of BEC and …

The blood vasculature regulates both the development and function of secondary lymphoid
organs by providing a portal for entry of hemopoietic cells. During the development of …

The humoral immune response and antibody-mediated functions of B cells during viral
infections are well described. However, we have limited understanding of antibody …

Protection from yearly recurring, highly acute infections with a pathogen that rapidly and
continuously evades previously induced protective neutralizing Abs, as seen during …

The stromal scaffold of the lymph node (LN) paracortex is built by fibroblastic reticular cells
(FRCs). Conditional ablation of lymphotoxin-β receptor (LTβR) expression in LN FRCs and …