Methylglyoxal and its adducts: Induction, repair, and association with disease

SWT Lai, EDJ Lopez Gonzalez, T Zoukari… - Chemical research in …, 2022 - ACS Publications
Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

Targeting RAGE signaling in inflammatory disease

BI Hudson, ME Lippman - Annual review of medicine, 2018 - annualreviews.org
The receptor for advanced glycation end-products (RAGE) is a multiligand pattern
recognition receptor implicated in diverse chronic inflammatory states. RAGE binds and …

Targeting the receptor for advanced glycation endproducts (RAGE): a medicinal chemistry perspective

S Bongarzone, V Savickas, F Luzi… - Journal of medicinal …, 2017 - ACS Publications
The receptor for advanced glycation endproducts (RAGE) is an ubiquitous, transmembrane,
immunoglobulin-like receptor that exists in multiple isoforms and binds to a diverse range of …

The role of advanced glycation end products in various types of neurodegenerative disease: a therapeutic approach

P Salahuddin, G Rabbani, R Khan - Cellular and Molecular Biology …, 2014 - degruyter.com
Protein glycation is initiated by a nucleophilic addition reaction between the free amino
group from a protein, lipid or nucleic acid and the carbonyl group of a reducing sugar. This …

Molecular characteristics of RAGE and advances in small-molecule inhibitors

HJ Kim, MS Jeong, SB Jang - International journal of molecular sciences, 2021 - mdpi.com
Receptor for advanced glycation end-products (RAGE) is a member of the immunoglobulin
superfamily. RAGE binds and mediates cellular responses to a range of DAMPs (damage …

Receptor for advanced glycation end products (RAGE): a pivotal hub in immune diseases

Q Yue, Y Song, Z Liu, L Zhang, L Yang, J Li - Molecules, 2022 - mdpi.com
As a critical molecule in the onset and sustainment of inflammatory response, the receptor
for advanced glycation end products (RAGE) has a variety of ligands, such as advanced …

RAGE in the pathophysiology of skeletal muscle

F Riuzzi, G Sorci, R Sagheddu… - Journal of cachexia …, 2018 - Wiley Online Library
Emerging evidence suggests that the signalling of the Receptor for Advanced Glycation End
products (RAGE) is critical for skeletal muscle physiology controlling both the activity of …

Pivotal role of AGE-RAGE axis in brain aging with current interventions

N Vitorakis, C Piperi - Ageing Research Reviews, 2024 - Elsevier
Brain aging is characterized by several structural, biochemical and molecular changes
which can vary among different individuals and can be influenced by genetic, environmental …

Therapeutic potential of targeting the receptor for advanced glycation end products (RAGE) by small molecule inhibitors

H Singh, DK Agrawal - Drug development research, 2022 - Wiley Online Library
Receptor for advanced glycation end products (RAGE) is a 45 kDa transmembrane receptor
of immunoglobulin family that can bind to various endogenous and exogenous ligands and …

Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products

G Aldini, G Vistoli, M Stefek, N Chondrogianni… - Free radical …, 2013 - Taylor & Francis
The advanced glycoxidation end products (AGEs) and lipoxidation end products (ALEs)
contribute to the development of diabetic complications and of other pathologies. The review …