Severe, steroid‐resistant asthma is clinically and economically important since affected
individuals do not respond to mainstay corticosteroid treatments for asthma. Patients with …

Severe steroid-resistant asthma is clinically important, as patients with this form of the
disease do not respond to mainstay corticosteroid therapies. The heterogeneity of this form …

Background Severe steroid-insensitive asthma is a substantial clinical problem. Effective
treatments are urgently required, however, their development is hampered by a lack of …

Abnormality in mitochondria has been suggested to be associated with development of
allergic airway disorders. In this study, to evaluate the relationship between mitochondrial …

Allergic asthma has been considered as a respiratory disorder with pathological features of
airway inflammation and remodeling, which involves oxidative stress. Formononetin (FMT) is …

Interleukin (IL)-33 is a recently described member of the IL-1 family and has been shown to
induce production of T helper type 2 cytokines. In this study, an anti-IL-33 antibody was …

P110δ phosphoinositide 3‐kinase (PI3K) plays a pivotal role in the recruitment and
activation of certain inflammatory cells. Recent findings revealed that the activity of p110δ …

Phosphoinositide 3-kinase (PI3K) is thought to contribute to the pathogenesis of asthma by
effecting the recruitment, activation, and apoptosis of inflammatory cells. We examined the …

Rationale: Myofibroblasts are primary effector cells in idiopathic pulmonary fibrosis (IPF).
Defining mechanisms of myofibroblast differentiation may be critical to the development of …

Background Despite many studies on endoplasmic reticulum (ER) stress in patients with
various inflammatory diseases, there is scarce information on ER stress in patients with …