The effect of natural antioxidants in cyclophosphamide-induced hepatotoxicity: Role of Nrf2/HO-1 pathway

IO Sherif - International immunopharmacology, 2018 - Elsevier
Hepatotoxicity induced by cyclophosphamide (Cyclo) is a major concern in clinical practice.
This study was designed to investigate the possible cytoprotective effect of natural …

New insights for the use of quercetin analogs in cancer treatment

D Iacopetta, F Grande, A Caruso… - Future medicinal …, 2017 - Taylor & Francis
Aim: Quercetin (Q1) is a flavonoid widely present in plants and endowed with several
pharmacological properties mostly due to its antioxidant potential. Q1 shows anticancer …

Protection of Quercetin against Triptolide-induced apoptosis by suppressing oxidative stress in rat Leydig cells

J Hu, Q Yu, F Zhao, J Ji, Z Jiang, X Chen, P Gao… - Chemico-Biological …, 2015 - Elsevier
Triptolide (TP) is a diterpene triepoxide with variety biological activities, such as anti-
inflammatory, anti-cancerogenic, immunomodulatory and pro-apoptotic activities. However …

[HTML][HTML] Pathological and pharmacovigilance monitoring as toxicological imputations of azithromycin and its residues in broilers

A Fotouh, DS Abdel-Maguid, M Abdelhaseib… - Veterinary …, 2024 - pmc.ncbi.nlm.nih.gov
Materials and Methods: One hundred and twenty chicks were distributed into four equal
groups randomly. Each group received different daily oral doses of Az: 200 mg/kg for Az1 …

Glutathione homeostasis is significantly altered by quercetin via the Keap1/Nrf2 and MAPK signaling pathways in rats

W Gao, L Pu, M Chen, J Wei, Z Xin, Y Wang… - Journal of Clinical …, 2018 - jstage.jst.go.jp
抄録 Previously, we showed that 0.5% quercetin simultaneously decreased serum
homocysteine and glutathione (GSH) levels in rats. The aim of the present study was to …

[HTML][HTML] Effects of quercetin on bisphenol A-induced mitochondrial toxicity in rat liver

M Mahdavinia, S Alizadeh, AR Vanani… - Iranian journal of …, 2019 - ncbi.nlm.nih.gov
Objective (s): Recognized as a distinguished environmental and global toxicant, Bisphenol
A (BPA) affects the liver, which is a vital body organ, by the induction of oxidative stress. The …

Gibberellic acid‐induced hepatorenal dysfunction and oxidative stress: mitigation by quercetin through modulation of antioxidant, anti‐inflammatory, and antiapoptotic …

MM Soliman, A Gaber, WF Alsanie… - Journal of Food …, 2022 - Wiley Online Library
The plant growth regulator gibberellic acid (GA3) is widely used in agriculture in many
countries. However, little is known about its danger to human health or its physiologic and …

Flavonoids-mediated TLR4 inhibition as a promising therapy for renal diseases

AM Mahmoud, AM Sayed, AF Ahmeda… - … Chemistry & High …, 2023 - ingentaconnect.com
Toll-like receptors (TLRs) control both innate and adaptive immunity with a wide expression
on renal epithelial cells and leukocytes. Activation of TLRs results in the production of …

Juvenile exposure and adult risk assessment with single versus repeated exposure of melphalan in the germ cells of male SD rat: deciphering the molecular …

A Panghal, C Sahu, S Singla, G Jena - Reproductive Toxicology, 2022 - Elsevier
Melphalan significantly contributes to the increase in childhood cancer survival rate. It acts
as a gonadotoxic agent and leads to testes damage, dysbalance in gonadal hormones, and …

The apoptotic and autophagic properties of two natural occurring prodrugs, hyperoside and hypoxoside, against pancreatic cancer cell lines

GJ Boukes, M van de Venter - Biomedicine & Pharmacotherapy, 2016 - Elsevier
Pancreatic cancer is only the 12th most common cancer, but the fourth leading cause of
cancer-related deaths in the world. This is due to late prognosis, poor response to …