Saporin from Saponaria officinalis as a Tool for Experimental Research, Modeling, and Therapy in Neuroscience

AP Bolshakov, MY Stepanichev, YV Dobryakova… - Toxins, 2020 - mdpi.com
Saporin, which is extracted from Saponaria officinalis, is a protein toxin that inactivates
ribosomes. Saporin itself is non-selective toxin but acquires high specificity after conjugation …

Alzheimer's Disease: An Attempt of Total Recall

AP Bolshakov, K Gerasimov… - Journal of Alzheimer's …, 2024 - journals.sagepub.com
This review is an attempt to compile existing hypotheses on the mechanisms underlying the
initiation and progression of Alzheimer's disease (AD), starting from sensory impairments …

The role of TrkB receptor signaling in Alzheimer's disease

K He, L Nie, Z Dai, S Li, X Yang, G Liu - Human Brain, 2023 - eaapublishing.org
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders among
the elderly. However, there is no reliable drug for the treatment of AD, which is largely due to …

[PDF][PDF] Reproductive and Developmental Toxicity, and Neurotoxicity of a Tropomyosin-Related Kinase A Inhibitor, ASP7962, in Rats

木上大輔, キガミダイスケ - 2023 - tsukuba.repo.nii.ac.jp
Background: Osteoarthritis (OA) is a cartilage degenerative disease and the most common
joint disorder. The expression levels of both nerve growth factor (NGF) and tropomyosin …

Neurotoxicity studies with a tropomyosin-related kinase A inhibitor, ASP7962, on the sympathetic and sensory nervous systems in rats

D Kigami, MT Butt, DL Brown, M Matsumoto, H Ito - Toxicology Letters, 2021 - Elsevier
ASP7962 is a small molecule inhibitor for the nerve growth factor (NGF) receptor,
tropomyosin-related kinase A (TrkA). NGF contributes to the survival of sensory and …

Novel Sites of Oxytocin Receptor Expression in the Mouse Periphery and Modulation of Pupillary Behavior by Oxytocin

MA Greenwood - 2019 - search.proquest.com
Oxytocin (OXT) is a peptide with important regulatory roles in both physiological and
behavioral contexts. OXT binds to the OXT receptor (OXTR) in the central and peripheral …

[引用][C] Sympathetic control of carotid body excitability in hypertension: A preclinical study

ISA Felippe - 2022 - ResearchSpace@ Auckland