The role of epithelial-mesenchymal transition in chronic rhinosinusitis

Y Xia, H Wang, J Yin - International Archives of Allergy and …, 2022 - karger.com
Background: Chronic rhinosinusitis (CRS) is a common condition in otorhinolaryngology. It
is characterized by chronic inflammation of the nasal cavity and the sinus mucosa. However …

Role of environmental air pollution in chronic rhinosinusitis

EM Leland, Z Zhang, KM Kelly… - Current allergy and asthma …, 2021 - Springer
Abstract Purpose of Review Chronic rhinosinusitis (CRS) is a highly prevalent disease with
large social and financial burdens. The pathophysiology is multifactorial. Environmental …

Protein stabilization of ITF2 by NF-κB prevents colitis-associated cancer development

M Lee, YS Kim, S Lim, SH Shin, I Kim, J Kim… - Nature …, 2023 - nature.com
Chronic colonic inflammation is a feature of cancer and is strongly associated with
tumorigenesis, but its underlying molecular mechanisms remain poorly understood …

TIM-4 in macrophages contributes to nasal polyp formation through the TGF-β1–mediated epithelial to mesenchymal transition in nasal epithelial cells

D Qin, P Liu, H Zhou, J Jin, W Gong, K Liu… - Frontiers in …, 2022 - frontiersin.org
Chronic rhinosinusitis with nasal polyps (CRSwNP) is caused by prolonged inflammation of
the paranasal sinus mucosa. The epithelial to mesenchymal transition (EMT) is involved in …

Gene–Smoking Interaction Analysis for the Identification of Novel Asthma-Associated Genetic Factors

J Cha, S Choi - International Journal of Molecular Sciences, 2023 - mdpi.com
Asthma is a complex heterogeneous disease caused by gene–environment interactions.
Although numerous genome-wide association studies have been conducted, these …

[HTML][HTML] Inhibition of IL-4/STAT6/IRF4 signaling reduces the epithelial-mesenchymal transition in eosinophilic chronic rhinosinusitis with nasal polyps

J Chen, S Chen, G Gong, F Yang, J Chen… - International …, 2023 - Elsevier
Background Previous studies have shown that epithelial-to-mesenchymal transition (EMT) in
nasal epithelial cells is critical for tissue remodeling of chronic rhinosinusitis with nasal …

[HTML][HTML] Oridonin alleviates cigarette smoke-induced nasal polyp formation by promoting autophagy

P Liu, X Wu, H Lv, J Huang, T Gu, D Liu, Y Xu - Biomedicine & …, 2024 - Elsevier
Previous studies have indicated that oridonin is a promising candidate for therapeutic
intervention in a range of inflammatory diseases. The objective of this study was to …

[HTML][HTML] Diesel exhaust particle exposure exacerbates ciliary and epithelial barrier dysfunction in the multiciliated bronchial epithelium models

E Park, BY Kim, S Lee, KH Son, J Bang… - Ecotoxicology and …, 2024 - Elsevier
Airway epithelium, the first defense barrier of the respiratory system, facilitates mucociliary
clearance against inflammatory stimuli, such as pathogens and particulates inhaled into the …

miR‐200a‐3p regulates epithelial–mesenchymal transition and inflammation in chronic rhinosinusitis with nasal polyps by targeting ZEB1 via ERK/p38 pathway

Y Wu, K Sun, Y Tu, P Li, D Hao, P Yu… - … Forum of Allergy & …, 2024 - Wiley Online Library
Background Several biological processes are regulated by miR‐200a‐3p, including cell
proliferation, migration, and epithelial–mesenchymal transition (EMT). In this study we aimed …

CBX4 plays a bidirectional role in transcriptional regulation and lung adenocarcinoma progression

R Zhao, Y Guo, L Zhang, Z Huang, X Li, B Lan… - Cell Death & …, 2024 - nature.com
Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality
worldwide. Understanding the dysregulated epigenetics governing LUAD progression is …