Background. Data from the largest randomized, controlled trial for the treatment of children
hospitalized with severe malaria were used to identify such predictors of a poor outcome …

OBJECTIVE. Our goal was to compare the efficacy and safety of buccal midazolam with
rectal diazepam in the treatment of prolonged seizures in Ugandan children. METHODS …

ContextPlasmodium falciparum appears to have a particular propensity to involve the brain
but the burden, risk factors, and full extent of neurological involvement have not been …

Strategies to Reduce Mortality from Bacterial Sepsis in Adults in Developing Countries | PLOS
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Background For a full treatment course of severe malaria, community-administered pre-
referral rectal artesunate (RAS) should be completed by post-referral treatment consisting of …

Although hyponatremia occurs in most patients with severe malaria, its pathogenesis,
prognostic significance, and optimal management have not been established. Clinical and …

Background Agro-ecological systems have been associated with increased malaria
intensity. This study determined association between different agro-ecological systems …

Background Severely ill patients with malaria with vomiting, prostration, and altered
consciousness cannot be treated orally and need injections. In rural areas, access to health …

Background Severe malaria has a case fatality rate of 10-20%; however, few studies have
addressed the quality of severe malaria case management. This study evaluated the …

Cerebral malaria is the most severe and rapidly fatal complication of Plasmodium falciparum
infection. Despite appropriate anti-malarial treatment using quinine or artemisinin …