The ability to measure the abundance of many proteins precisely and simultaneously in
experimental samples is an important, recent advance for static and dynamic, as well as …

Protein biochips are at the heart of many medical and bioanalytical applications. Increasing
interest has been focused on surface activation and subsequent functionalization strategies …

Background Most patients with non–small-cell lung cancer have no response to the tyrosine
kinase inhibitor gefitinib, which targets the epidermal growth factor receptor (EGFR) …

Genome sequences are now available that enable us to determine the biological
components that make up a cell or an organism. The discipline of systems biology examines …

The study of cellular signalling over the past 20 years and the advent of high-throughput
technologies are enabling the reconstruction of large-scale signalling networks. After careful …

Signal transduction pathways control cellular responses to stimuli, but it is unclear how
molecular information is processed as a network. We constructed a systems model of 7980 …

We provide analysis of different regimes of diffusion and laminar flow convection combined
with bimolecular surface reactions relevant to biochemical assays performed in microfluidic …

Protein microarrays present an innovative and versatile approach to study protein
abundance and function at an unprecedented scale. Given the chemical and structural …

Antibody arrays have valuable applications in cancer research. Many different antibody
array technologies have been developed, each with particular advantages, disadvantages …

Antibody arrays have evolved into powerful tools for quantifying proteins and qualifying their
state of activation in complex biological samples. This level of analysis holds tremendous …