This year celebrates the 50th anniversary of the Singer-Nicolson fluid mosaic model for
biological membranes. The next level of sophistication we have achieved for understanding …

The epidermal growth factor (EGF) system has allowed chemists, biologists, and clinicians to
improve our understanding of cell production and cancer therapy. The discovery of EGF led …

The nanoscale arrangement of ligands can have a major effect on the activation of
membrane receptor proteins and thus cellular communication mechanisms. Here we report …

The RecA protein and RecBCD complex are key bacterial components for the maintenance
and repair of DNA. RecBCD is a helicase-nuclease that uses homologous recombination to …

In many eukaryotic algae, CO 2 fixation by Rubisco is enhanced by a CO 2-concentrating
mechanism, which utilizes a Rubisco-rich organelle called the pyrenoid. The pyrenoid is …

The ability of tumors to establish a pro-tumorigenic microenvironment is an important point of
investigation in the search for new therapeutics. Tumors form microenvironments in part by …

DNA replication in all organisms must overcome nucleoprotein blocks to complete genome
duplication. Accessory replicative helicases in Escherichia coli, Rep and UvrD, help remove …

Epigenetic regulation maintains gene expression patterns over many rounds of cell division
in higher organisms. However, visualization of factors regulating epigenetic switches in vivo …

Cellular communication is regulated at the plasma membrane by the interactions of receptor,
adhesion, signaling, exocytic, and endocytic proteins. Yet, the composition and control of …

Cells employ myriad regulatory mechanisms to maintain protein homeostasis, termed
proteostasis, to ensure correct cellular function. Dysregulation of proteostasis, which is often …