[HTML][HTML] Worldwide burden of, risk factors for, and trends in pancreatic cancer

J Huang, V Lok, CH Ngai, L Zhang, J Yuan, XQ Lao… - Gastroenterology, 2021 - Elsevier
Background & Aims We evaluated global and regional burdens of, risk factors for, and
epidemiologic trends in pancreatic cancer among groups of different sexes and ages …

The use of antihypertensive drugs as coadjuvant therapy in cancer

JA Carlos-Escalante, M de Jesus-Sanchez… - Frontiers in …, 2021 - frontiersin.org
Cancer is a complex group of diseases that constitute the second largest cause of mortality
worldwide. The development of new drugs for treating this disease is a long and costly …

Neural component of the tumor microenvironment in pancreatic ductal adenocarcinoma

M Gola, A Sejda, J Godlewski, M Cieślak, A Starzyńska - Cancers, 2022 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal
cancers worldwide, with a poor prognosis and an increasing incidence. Recently, the tumor …

Temporality of body mass index, blood tests, comorbidities and medication use as early markers for pancreatic ductal adenocarcinoma (PDAC): a nested case–control …

P San Tan, C Garriga, A Clift, W Liao, M Patone… - Gut, 2023 - gut.bmj.com
Objective Prior studies identified clinical factors associated with increased risk of pancreatic
ductal adenocarcinoma (PDAC). However, little is known regarding their time-varying …

Prioritization of regulatory variants with tissue-specific function in the non-coding regions of human genome

S Dong, AP Boyle - Nucleic acids research, 2022 - academic.oup.com
Understanding the functional consequences of genetic variation in the non-coding regions
of the human genome remains a challenge. We introduce h ere a computational tool, TURF …

Calcium release-activated calcium (CRAC) channel inhibition suppresses pancreatic ductal adenocarcinoma cell proliferation and patient-derived tumor growth

HY Khan, GB Mpilla, R Sexton, S Viswanadha… - Cancers, 2020 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) remains an unmet clinical problem in urgent
need of newer molecularly driven treatment modalities. Calcium signals, particularly those …

Unravelling the tangled web of hypertension and cancer

A Sionakidis, L McCallum, S Padmanabhan - Clinical Science, 2021 - portlandpress.com
Cardiovascular disease remains the primary cause of mortality globally, being responsible
for an estimated 17 million deaths every year. Cancer is the second leading cause of death …

The therapeutic potential of renin-angiotensin system inhibitors in the treatment of pancreatic cancer

N Khoshghamat, N Jafari, V Toloue-Pouya, S Azami… - Life Sciences, 2021 - Elsevier
Pancreatic cancer is among the most lethal malignancies with poor prognosis and patients
become chemoresistant to current therapies, supporting further investigations to identify new …

Antihypertensive drugs and cancer risk

S Kidoguchi, N Sugano, T Yokoo… - American Journal of …, 2022 - academic.oup.com
Hypertension is the most prevalent comorbidity in cancer patients. Consequently, many
cancer patients are prescribed antihypertensive drugs before cancer diagnosis or during …

Antihypertensive agents: a long way to safe drug prescribing in children

N Siddiqi, IF Shatat - Pediatric Nephrology, 2020 - Springer
Recently updated clinical guidelines have highlighted the gaps in our understanding and
management of pediatric hypertension. With increased recognition and diagnosis of …