Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …

The identification of new bioactive compounds derived from medicinal plants with significant
therapeutic properties has attracted considerable interest in recent years. Such is the case of …

Zinc oxide nanoparticles (nano-ZnO) are one of the most important nanoparticles in the
industry. The objectives of this study were (1) to investigate the effects of nano-ZnO on …

Cancer is one of the world's biggest healthcare burdens and despite the current
advancements made in treatment plans, the outcomes for oncology patients have yet to …

Abstract Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase that
regulates many cellular processes. Given the central role of PP2A in regulating diverse …

Triptolide and celastrol are predominantly active natural products isolated from the
medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar …

Osteosarcoma is the most common primary malignant tumor of bone, the long-term survival
of which has stagnated in the past several decades. Celastrol, a triterpene from traditional …

Celastrol, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has gained
extensive exploration due to its unique structure features and multiple promising biological …

Despite the advancement in the well-equipped and sophisticated laboratories and facilities,
cancer remains to be a major cause of death worldwide. Consequently, further investigation …

As a terpenoids natural product isolated from the plant Thunder God Vine, Celastrol is
widely studied for its pharmacological activities, including anti-tumor activities. The clinical …