NRF2 inhibitors: Recent progress, future design and therapeutic potential

B Lv, S Xing, Z Wang, A Zhang, Q Wang, Y Bian… - European Journal of …, 2024 - Elsevier
Nuclear factor erythroid 2-related factor 2 (NRF2) is a crucial transcription factor involved in
oxidative stress response, which controls the expression of various cytoprotective genes …

[HTML][HTML] The multi-faceted consequences of NRF2 activation throughout carcinogenesis

CJ Occhiuto, JA Moerland, AS Leal, KA Gallo… - Molecules and cells, 2023 - Elsevier
The oxidative balance of a cell is maintained by the Kelch-like ECH-associated protein 1
(KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway. This cytoprotective …

Stapled peptides as direct inhibitors of Nrf2-sMAF transcription factors

R Modi, N McKee, N Zhang, A Alwali… - Journal of Medicinal …, 2023 - ACS Publications
Nuclear factor erythroid-related 2-factor 2 (Nrf2) is a transcription factor traditionally thought
of as a cellular protector. However, in many cancers, Nrf2 is constitutively activated and …

[HTML][HTML] Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2

B Buttari, A Tramutola, AI Rojo, N Chondrogianni… - Biomolecules, 2025 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (NRF2) is a master regulator of cellular
homeostasis, overseeing the expression of a wide array of genes involved in cytoprotective …

[HTML][HTML] Luminescence-based complementation assay to assess target engagement and cell permeability of glycolate oxidase (HAO1) inhibitors

SR Mackinnon, T Zarganes-Tzitzikas, CJ Adams… - Biochimie, 2025 - Elsevier
Glycolate oxidase (HAO1) catalyses the synthesis of glyoxylate, a common metabolic
intermediate that causes renal failure if accumulated. HAO1 inhibition is an emerging …

State‐of‐the‐Art Nrf2 Inhibitors: Therapeutic Opportunities in Non‐Cancer Diseases

EG Ayala‐Cosme, D Yang, K Vences… - …, 2024 - Wiley Online Library
Nuclear factor erythroid 2‐related factor (Nrf2) is a cytoprotective transcription factor that
induces the transcription of genes responsible for the cell's response to oxidative stress …

Design and synthesis of Nrf2-derived hydrocarbon stapled peptides for the disruption of protein-DNA-interactions

B Wiedemann, D Kamps, L Depta, J Weisner… - Plos one, 2022 - journals.plos.org
Misregulation and mutations of the transcription factor Nrf2 are involved in the development
of a variety of human diseases. In this study, we employed the technology of stapled …

Scope of Theoretical Approaches Studying the Ligand-Nrf2

EO Madrigal-Santillán… - The Role of NRF2 …, 2024 - books.google.com
The nuclear factor erythroid 2-related factor 2 (Nrf2) is a protein transcrip-tional factor
considered as an emerging target for multiple biological processes. Its study could be useful …

An Investigation of the Regulatory Relationship of the Keap1/Nrf2/ARE Signaling System and Transcriptional Regulators of Lysosomal Biogenesis

AV Chechushkov, EB Menshchikova - Cell and Tissue Biology, 2023 - Springer
Despite the key role of the Keap1/Nrf2/ARE redox-sensitive signaling system in cell
metabolism, almost nothing is known about its association with lysosome biogenesis. In the …

[HTML][HTML] Stapled peptides: targeting protein-protein interactions in drug development

Q Zhang, Z Wang, X Mei, Q Chen… - Exploration of Drug …, 2024 - explorationpub.com
Protein-protein interactions (PPIs) impersonate a significant role in many biological
processes and are potential therapeutic targets in numerous human diseases. Stapled …