Emerging concepts in the science of vaccine adjuvants

B Pulendran, P S. Arunachalam… - Nature Reviews Drug …, 2021 - nature.com
Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …

Human immunodeficiency virus (HIV)

German Advisory Committee Blood … - Transfusion medicine …, 2016 - karger.com
German Advisory Committee Blood (Arbeitskreis Blut), Subgroup 'Assessment of Pathogens
Transmissible by Blood'tein, TM) are derived. In addition to the structural proteins, the HIV …

[HTML][HTML] HIV-1 Tat: role in bystander toxicity

D Ajasin, EA Eugenin - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
HIV Tat protein is a critical protein that plays multiple roles in HIV pathogenesis. While its
role as the transactivator of HIV transcription is well established, other roles associated with …

Viral and cellular factors underlying neuropathogenesis in HIV associated neurocognitive disorders (HAND)

VR Rao, AP Ruiz, VR Prasad - AIDS research and therapy, 2014 - Springer
As the HIV-1 epidemic enters its fourth decade, HIV-1 associated neurological disorders
(HAND) continue to be a major concern in the infected population, despite the widespread …

Cerebrospinal fluid immune markers and HIV-associated neurocognitive impairments: A systematic review

ME Williams, DJ Stein, JA Joska, PJW Naudé - Journal of …, 2021 - Elsevier
HIV-1 is responsible for the development of a spectrum of cognitive impairments known as
HIV-associated neurocognitive disorder (HAND). In the era of antiretroviral therapy (ART) …

Risk factors and pathogenesis of HIV-associated neurocognitive disorder: the role of host genetics

IS Olivier, R Cacabelos, V Naidoo - International journal of molecular …, 2018 - mdpi.com
Neurocognitive impairments associated with human immunodeficiency virus (HIV) infection
remain a considerable health issue for almost half the people living with HIV, despite …

The relationship between HIV‐1 neuroinflammation, neurocognitive impairment and encephalitis pathology: A systematic review of studies investigating post‐mortem …

ME Williams, PJW Naudé - Reviews in Medical Virology, 2024 - Wiley Online Library
The activities of HIV‐1 in the central nervous system (CNS) are responsible for a
dysregulated neuroinflammatory response and the subsequent development of HIV …

Opioid and neuroHIV comorbidity–current and future perspectives

S Fitting, MP McRae, KF Hauser - Journal of Neuroimmune Pharmacology, 2020 - Springer
With the current national opioid crisis, it is critical to examine the mechanisms underlying
pathophysiologic interactions between human immunodeficiency virus (HIV) and opioids in …

[HTML][HTML] Association of maternal and infant inflammation with neurodevelopment in HIV-exposed uninfected children in a South African birth cohort

T Sevenoaks, CJ Wedderburn, KA Donald… - Brain, Behavior, and …, 2021 - Elsevier
HIV-exposed uninfected (HEU) children may have altered immune regulation and poorer
neurodevelopment outcomes compared to their HIV-unexposed (HU) counterparts …

[HTML][HTML] Signatures of HIV-1 subtype B and C Tat proteins and their effects in the neuropathogenesis of HIV-associated neurocognitive impairments

ME Williams, SS Zulu, DJ Stein, JA Joska… - Neurobiology of …, 2020 - Elsevier
HIV-associated neurocognitive impairments (HANI) are a spectrum of neurological disorders
due to the effects of HIV-1 on the central nervous system (CNS). The HIV-1 subtypes; HIV-1 …