A unique organelle for studying membrane biochemistry is the mitochondrion whose
functionality depends on a coordinated supply of proteins and lipids. Mitochondria are …

Due to its genetic tractability and increasing wealth of accessible data, the yeast
Saccharomyces cerevisiae is a model system of choice for the study of the genetics …

Mitochondria must maintain adequate amounts of metabolites for protective and biosynthetic
functions. However, how mitochondria sense the abundance of metabolites and regulate …

Since it has been recognized that mitochondria are crucial not only for energy metabolism
but also for other cellular functions, there has been a growing interest in cardiolipin, the …

Membrane biology seeks to understand how lipids and proteins within bilayers assemble
into large structures such as organelles and the plasma membranes. Historically, lipids were …

In this article, the formation of prokaryotic and eukaryotic cardiolipin is reviewed in light of its
biological function. I begin with a detailed account of the structure of cardiolipin, its …

Barth syndrome is an X-linked genetic disorder caused by mutations in the tafazzin (taz)
gene and characterized by dilated cardiomyopathy, exercise intolerance, chronic fatigue …

Tafazzin is a putative enzyme that is involved in cardiolipin metabolism, it may carry
mutations responsible for Barth syndrome. To identify the biochemical reaction catalyzed by …

Mitochondria are dynamic organelles of endosymbiotic origin that are essential components
of eukaryal cells. They contain their own genetic machinery, have multicopy genomes and …

Prohibitins form large protein and lipid scaffolds in the inner membrane of mitochondria that
are required for mitochondrial morphogenesis, neuronal survival, and normal lifespan. Here …