Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

Macrocyclic chelators can form highly stable complexes with transition metals and
lanthanides. In this review, the recent advances towards biomedical applications of …

Chemokines are key players in the attraction and activation of leukocytes and are thus
implicated in the recruitment of immune cells at sites of infection and/or inflammation. They …

The chemokine receptor CXCR4 and its cognate ligand CXCL12 are pivotal for establishing
metastases from many tumor types. Thus, CXCR4 may offer a cell surface target for …

AMD3100 was originally discovered as an anti-HIV agent effective in inhibiting the
replication of HIV in vitro at nanomolar concentrations. We found it to be a potent and …

The original bicyclam, JM1657 (JM standing for Johnson Matthey) was discovered as a
contaminant in a commercial preparation of monocyclams when evaluated for their anti-HIV …

The role of MRI differs considerably between the three main groups of hematological
malignancies: lymphoma, leukemia, and myeloma. In myeloma, whole‐body MRI (WB‐MRI) …

Using transition metals such as manganese (II), iron (II), cobalt (II), nickel (II), copper (II), and
zinc (II), several new metal complexes of cross-bridged tetraazamacrocyclic chelators …

The chemokine receptor CXCR4 is a critical regulator of inflammation and immune
surveillance, and it is specifically implicated in cancer metastasis and HIV-1 infection. On the …

Simple Summary Preliminary evidence about the useful impact of [68Ga] Ga-Pentixafor
PET/CT or PET/MRI in lymphoma is available but reveals heterogeneous findings. The aim …