There is now compelling evidence that the complexity of higher organisms correlates with
the relative amount of non-coding RNA rather than the number of protein-coding genes …

Alternative polyadenylation (APA) is emerging as a widespread mechanism used to control
gene expression. Like alternative splicing, usage of alternative poly (A) sites allows a single …

Protein synthesis is often regulated at the level of initiation of translation, making it a critical
step. This regulation occurs by both the cis‐regulatory elements, which are located in the …

Recent advances in the understanding of the molecular mechanism of mRNA 3′ end
processing have uncovered a previously unanticipated integrated network of transcriptional …

The number of reported germline mutations in human nuclear genes, either underlying or
associated with inherited disease, has now exceeded 100,000 in more than 3,700 different …

Neuromuscular junctions (NMJs) are synapses that transmit impulses from motor neurons to
skeletal muscle fibers leading to muscle contraction. Study of hereditary disorders of …

IFNL3, which encodes interferon-λ3 (IFN-λ3), has received considerable attention in the
hepatitis C virus (HCV) field, as many independent genome-wide association studies have …

Structural characteristics are essential for the functioning of many noncoding RNA s and cis‐
regulatory elements of m RNA s. SNP s may disrupt these structures, interfere with their …

Extensive genetic studies of chronic pancreatitis over the past decade have highlighted the
importance of a tightly regulated balance between activation and inactivation of trypsin …

Genome-wide association studies have identified several risk associations for ovarian
carcinomas but not for mucinous ovarian carcinomas (MOCs). Our analysis of 1,644 MOC …