Airway remodelling is an important feature of asthma pathogenesis. A key structural change
inherent in airway remodelling is increased airway smooth muscle mass. There is emerging …

The peroxisome proliferator-activated receptors (PPARs) and the retinoid X receptors
(RXRs) are ligand-activated transcription factors that coordinately regulate gene expression …

Rationale: Portopulmonary hypertension (PPHTN) occurs in 6% of liver transplant
candidates. The pathogenesis of this complication of portal hypertension is poorly …

Pancreatic cancer is a largely incurable disease, and increasing evidence supports
strategies targeting multiple molecular mediators of critical functions of pancreatic ductal …

Significance: Pulmonary hypertension is a devastating disorder without any available
treatment strategies that satisfactorily promote the survival of patients. The identification of …

Pulmonary arterial hypertension (PAH) is a progressive disorder leading to occlusive
vascular remodeling. Current PAH therapies improve quality of life but do not reverse …

Airway remodeling in chronic asthma is characterized by increased smooth muscle mass
that is associated with the reduction of the bronchial lumen as well as airway …

Pulmonary arterial hypertension (PAH) is a multifactorial disease characterized by interplay
of many cellular, molecular, and genetic events that lead to excessive proliferation of …

Background: Previous studies revealed that the gene signatures are associated with the
modulation and pathogenesis of pulmonary arterial hypertension (PAH). However …

Pulmonary hypertension (PH) and its severe subtype pulmonary arterial hypertension (PAH)
encompass a set of multifactorial diseases defined by sustained elevation of pulmonary …