Hypertension is a complex multifactorial disorder with genetic, environmental and
demographic factors contributing to its prevalence. The genetic element contribution to …

Hypertension is a complex genetic disorder caused by interplay between several 'risk'genes
and environmental factors (genetic heritability∼ 30%). Most genetic studies of hypertension …

Animal microRNAs (miRNAs) regulate gene expression through base pairing to their targets
within the 3′ untranslated region (UTR) of protein-coding genes. Single-nucleotide …

The recent completion of the Human Genome Project has provided an unprecedented
opportunity for researchers to identify high-risk patients and improve human health through …

The angiotensin II type 1 receptor (AGTR1) plays an integral role in blood pressure control,
and is implicated in the pathogenesis of hypertension. Polymorphisms within this gene have …

Patients vary considerably in their response to drug therapy. A drug that proves to be
pharmacologically effective in some patients at a given dose may be ineffective or even toxic …

Background: Previous studies have shown that angiotensin II AT1 receptor gene (AT1R)
polymorphisms are associated with the risk for hypertension. However, the results remain …

Background: Hypertension is a serious health issue worldwide and essential hypertension,
which includes 90–95% of the cases, is influenced by both genetic and environmental …

Abstract Background and Aims The principal biologic effects of the renin-angiotensin system
are mediated by activation of the AT1R receptor. The microRNA miR-155 regulates AT1R …

Background. Essential hypertension is the result of modifiable and genetic factors, and it is
associated with increased risk for atherothrombosis. Some polymorphisms are associated …