The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members)
has been implicated in cancer and other human diseases. However, in contrast to the direct …

The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

Rho GTPases control many aspects of cell behavior through the regulation of multiple signal
transduction pathways (Van Aelst and D'Souza-Schorey 1997; Hall 1998). Rho, Rac, and …

A biologically active complementary DNA clone of a transforming gene present in a human
colon carcinoma contains gene sequences of both tropomyosin and a previously unknown …

Summary The Rho subfamily of GTPases is involved in controlof cell morphology in
mammals and yeast. The mammalian Rac and Cdc42 proteins control formation of …

The met oncogene activated in vitro by treatment of a human osteogenic sarcoma (HOS) cell
line with N-methyl-N'-nitronitrosoguanidine(MNNG) is related to the tyrosine kinase gene …

Using DNA transfection analysis1 on NIH3T3 cells2, activated human oncogenes have been
isolated from a variety of fresh solid tumours3. Thyroid neoplasias show a wide range of …

Abstract The Rho family of GTPases represents a class of Ras-related signaling molecules
often deregulated in cancer. Rho GTPases switch from a GDP-bound, inactive state to a GTP …

▪ Abstract The actin cytoskeleton is a highly dynamic network composed of actin polymers
and a large variety of associated proteins. The main functions of the actin cytoskeleton are to …

Proteins that associate with the GTP‐bound forms of the Ras superfamily of proteins are
potential effector targets for these molecular switches. A 195 kDa protein was purified from …