The perspective reviews quantitative investigations of chemical exchange phenomena in
proteins and other biological macromolecules using NMR spectroscopy, particularly …

The ubiquitous heat shock protein 70 (HSP70) family consists of ATP-dependent molecular
chaperones, which perform numerous cellular functions that affect almost all aspects of the …

The processes of genome replication and transcription of SARS-CoV-2 represent important
targets for viral inhibition. Betacoronaviral nucleoprotein (N) is a highly dynamic cofactor of …

The anti-cancer drug target poly (ADP-ribose) polymerase 1 (PARP1) and its close
homologue, PARP2, are early responders to DNA damage in human cells,. After binding to …

Liquid–liquid phase separation of flexible biomolecules has been identified as a ubiquitous
phenomenon underlying the formation of membraneless organelles that harbor a multitude …

The nucleolus is a membrane-less organelle formed through liquid-liquid phase separation
of its components from the surrounding nucleoplasm. Here, we show that nucleophosmin …

The nucleocapsid protein of severe acute respiratory syndrome coronavirus 2 encapsidates
the viral genome and is essential for viral function. The central disordered domain comprises …

Despite the prominent role of the K-Ras protein in many different types of human cancer,
major gaps in atomic-level information severely limit our understanding of its functions in …

Amplification of chromosomal region 8p11–12 is a common genetic alteration that has been
implicated in the aetiology of lung squamous cell carcinoma (LUSC),–. The FGFR1 gene is …

Nuclear magnetic resonance (NMR) spectroscopy is a pivotal method for structure-based
and fragment-based lead discovery because it is one of the most robust techniques to …