The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in
nature for millions of years. The human infection, named Chagas disease, is a major public …

Chagas disease caused by the parasite Trypanosoma cruzi affects millions of people.
Although its first genome dates from 2005, its complexity hindered a complete assembly and …

Trypanosoma cruzi, the agent of Chagas disease, probably infects tens of millions of people,
primarily in Latin America, causing morbidity and mortality. The options for treatment and …

Trypanosoma cruzi is the etiologic agent of Chagas disease, and current methods for its
genetic manipulation have been highly inefficient. We report here the use of the CRISPR …

Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite,
Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global …

Background Due to the absence of transcription initiation regulation of protein coding genes
transcribed by RNA polymerase II, posttranscriptional regulation is responsible for the …

Trans-splicing of leader sequences onto the 5′ ends of mRNAs is a widespread
phenomenon in protozoa, nematodes and some chordates. Using parallel sequencing we …

Kinetoplastids, including the human pathogens Trypanosoma brucei, Trypanosoma cruzi
and Leishmania, are the only known organisms that do not regulate the transcription of …

In nearly all eukaryotes, cellular differentiation is governed by changes in transcription, and
stabilized by chromatin and DNA modification. Gene expression control in the pathogen …

Trypanosomatids are protozoan micro-organisms that cause serious health problems in
humans and domestic animals. In addition to their medical relevance, these pathogens have …