A global view of the genetic basis of Alzheimer disease

C Reitz, MA Pericak-Vance, T Foroud… - Nature Reviews …, 2023 - nature.com
The risk of Alzheimer disease (AD) increases with age, family history and informative genetic
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …

Reassessment of pioglitazone for Alzheimer's disease

AM Saunders, DK Burns, WK Gottschalk - Frontiers in neuroscience, 2021 - frontiersin.org
Alzheimer's disease is a quintessential 'unmet medical need', accounting for∼ 65% of
progressive cognitive impairment among the elderly, and 700,000 deaths in the United …

An overview of data integration in neuroscience with focus on Alzheimer's Disease

R Turrisi, M Squillario, G Abate… - IEEE Journal of …, 2023 - ieeexplore.ieee.org
This article represents the first attempt to provide an overview of how to face data integration
as the result of a dialogue between neuroscientists and computer scientists. Indeed, data …

Apolipoprotein A1, the neglected relative of Apolipoprotein E and its potential role in Alzheimer's disease

K Endres - Neural regeneration research, 2021 - journals.lww.com
Lipoproteins are multi-molecule assemblies with the primary function of transportation and
processing of lipophilic substances within aqueous bodily fluids (blood, cerebrospinal fluid) …

Improving genetic risk prediction across diverse population by disentangling ancestry representations

PK Gyawali, Y Le Guen, X Liu, ME Belloy… - Communications …, 2023 - nature.com
Risk prediction models using genetic data have seen increasing traction in genomics.
However, most of the polygenic risk models were developed using data from participants …

Wide and deep learning based approaches for classification of Alzheimer's disease using genome-wide association studies

AS Alatrany, W Khan, A Hussain, D Al-Jumeily… - Plos one, 2023 - journals.plos.org
The increasing incidence of Alzheimer's disease (AD) has been leading towards a
significant growth in socioeconomic challenges. A reliable prediction of AD might be useful …

A genome-wide association study reveals a polygenic architecture of speech-in-noise deficits in individuals with self-reported normal hearing

IS Bhatt, JAR Garay, SG Bhagavan, V Ingalls, R Dias… - Scientific Reports, 2024 - nature.com
Abstract Speech-in-noise (SIN) perception is a primary complaint of individuals with
audiometric hearing loss. SIN performance varies drastically, even among individuals with …

c-Diadem: a constrained dual-input deep learning model to identify novel biomarkers in Alzheimer's disease

S Jemimah, A AlShehhi… - BMC Medical …, 2023 - Springer
Background Alzheimer's disease (AD) is an incurable, debilitating neurodegenerative
disorder. Current biomarkers for AD diagnosis require expensive neuroimaging or invasive …

[HTML][HTML] GRM7 deficiency, from excitotoxicity and neuroinflammation to neurodegeneration: systematic review of GRM7 deficient patients

M Zaki-Dizaji, MF Abazari, H Razzaghi… - Brain, Behavior, & …, 2024 - Elsevier
The metabotropic glutamate receptor 7 (mGluR7) is a presynaptic G-protein-coupled
glutamate receptor that modulates neurotransmitter release and synaptic plasticity at …

The effect of data augmentation and 3D-CNN depth on Alzheimer's Disease detection

R Turrisi, A Verri, A Barla - arXiv preprint arXiv:2309.07192, 2023 - arxiv.org
Machine Learning (ML) has emerged as a promising approach in healthcare, outperforming
traditional statistical techniques. However, to establish ML as a reliable tool in clinical …