Sepsis is the life-threatening organ dysfunction caused by a dysregulated host response to
infection and is the leading cause of death in intensive care units. Cardiac dysfunction …

Sepsis is a common condition that is associated with unacceptably high mortality and, for
many of those who survive, long-term morbidity. Increased awareness of the condition …

Objective To provide an update to “Surviving Sepsis Campaign Guidelines for Management
of Sepsis and Septic Shock: 2012”. Design A consensus committee of 55 international …

Rationale: Recent retrospective evidence suggests the efficacy of early norepinephrine
administration during resuscitation; however, prospective data to support this assertion are …

Objective: To provide an update to the “Surviving Sepsis Campaign Guidelines for
Management of Severe Sepsis and Septic Shock,” last published in 2008. Design: A …

Background: To interpret blood pressure (BP) data appropriately, healthcare providers need
to be knowledgeable of the factors that can potentially impact the accuracy of BP …

Sepsis is considered a major public health problem. Despite mortality being associated
consistently with organ compromise, the mechanisms by which sepsis causes multiple …

Objective: To determine whether central venous pressure and fluid balance after
resuscitation for septic shock are associated with mortality. Design: We conducted a …

An understanding of the pathologic mechanisms of sepsis-induced AKI emphasizes the
important role of maladaptive responses to the septic insult. Preventive and therapeutic …

Aggressive fluid resuscitation to achieve a central venous pressure (CVP) greater than 8 mm
Hg has been promoted as the standard of care, in the management of patients with severe …