The endoplasmic reticulum (ER), which occupies a large portion of the cytoplasm, is the
cell's main site for the biosynthesis of lipids and carbohydrate conjugates, and it is essential …

Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous
neurological disorders characterized by pathophysiologic hallmark of length-dependent …

Axon outgrowth and guidance to the proper target requires the coordination of filamentous
(F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …

Mislocalization and aggregation of Aβ and Tau combined with loss of synapses and
microtubules (MTs) are hallmarks of Alzheimer disease. We exposed mature primary …

Voluntary movement is a fundamental way in which animals respond to, and interact with,
their environment. In mammals, the main CNS pathway controlling voluntary movement is …

Hereditary spastic paraplegias (HSPs; SPG1–45) are inherited neurological disorders
characterized by lower extremity spastic weakness. More than half of HSP cases result from …

The hereditary spastic paraplegias (HSPs) are a heterogeneous group of neurologic
disorders with the common feature of prominent lower-extremity spasticity, resulting from a …

Mutations in more than 70 distinct loci and more than 50 mutated gene products have been
identified in patients with hereditary spastic paraplegias, a diverse group of neurological …

Here we investigated whether the sensitivity of microtubules to severing by katanin is
regulated by acetylation of the microtubules. During interphase, fibroblasts display long …

Subcellular mislocalization of the microtubule-associated protein Tau is a hallmark of
Alzheimer disease (AD) and other tauopathies. Six Tau isoforms, differentiated by the …