Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective

X Chang, F Qu, C Li, J Zhang, Y Zhang… - Medicinal Research …, 2024 - Wiley Online Library
Unprecedented therapeutic targeting of previously undruggable proteins has now been
achieved by molecular‐glue‐mediated proximity‐induced degradation. As a small GTPase …

[HTML][HTML] A novel gene expression-based prognostic scoring system to predict survival in gastric cancer

P Wang, Y Wang, B Hang, X Zou, JH Mao - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Analysis of gene expression patterns in gastric cancer (GC) can help to identify a
comprehensive panel of gene biomarkers for predicting clinical outcomes and to discover …

Colchicine blocks tubulin heterodimer recycling by tubulin cofactors TBCA, TBCB, and TBCE

S Nolasco, J Bellido, M Serna, B Carmona… - Frontiers in cell and …, 2021 - frontiersin.org
Colchicine has been used to treat gout and, more recently, to effectively prevent
autoinflammatory diseases and both primary and recurrent episodes of pericarditis. The anti …

Clinicopathological features and CCT2 and PDIA2 expression in gallbladder squamous/adenosquamous carcinoma and gallbladder adenocarcinoma

Q Zou, Z Yang, Y Yuan, J Li, L Liang, G Zeng… - World journal of surgical …, 2013 - Springer
Background Gallbladder cancer (GBC) is a relatively uncommon carcinoma among
gastrointestinal cancers and usually has a rather poor prognosis. The most common subtype …

Development of an RNA sequencing‐based prognostic gene signature in multiple myeloma

M Zamani‐Ahmadmahmudi, SM Nassiri… - British Journal of …, 2021 - Wiley Online Library
Several prognostic gene signatures have been developed to predict the clinical outcome in
patients with multiple myeloma (MM). The most salient disadvantage of the previous …

Single-cell and bulk RNA-seq unveils the immune infiltration landscape associated with cuproptosis in cerebral cavernous malformations

C Chen, Y Bao, S Ju, C Jiang, X Zou, X Zhang… - Biomarker …, 2024 - Springer
Abstract Background Cerebral cavernous malformations (CCMs) are vascular abnormalities
associated with deregulated angiogenesis. Their pathogenesis and optimal treatment …

Peptides and combination of peptides for use in immunotherapy and methods for generating scaffolds for the use against pancreatic cancer and other cancers

M Andrea, T Weinschenk, O Schoor, J Fritsche… - US Patent …, 2019 - Google Patents
2016-06-17 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers

P Wagner, H Schuster, J Peper, K Röhle… - 2022 - Google Patents
NZ754139A - Novel peptides and combination of peptides for use in immunotherapy against
ovarian cancer and other cancers - Google Patents NZ754139A - Novel peptides and …

Differential expression of GSPT1 GGCn alleles in cancer

J Malta-Vacas, P Ferreira, C Monteiro, M Brito - Cancer genetics and …, 2009 - Elsevier
The human eukaryotic release factor 3a (eRF3a), encoded by the G1 to S phase transition 1
gene (GSPT1; alias eRF3a), is upregulated in various human cancers. GSPT1 contains a …

Peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers

M Andrea, T Weinschenk, H Hoerzer, O Schoor… - US Patent …, 2019 - Google Patents
The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the …