Trichloroethylene is an organic chemical that has been used in dry cleaning, for metal
degreasing, and as a solvent for oils and resins. It has been shown to cause liver and kidney …

This article focuses on the various models for kidney toxicity due to trichloroethylene (TCE)
and its glutathione-dependent metabolites, in particular S-(1, 2-dichlorovinyl)-l-cysteine …

Trichloroethylene (TCE) is an important solvent that is widespread in the environment. We
have reviewed carcinogenicity data from seven bioassays with regard to renal injury and …

Healthy male and female human volunteers were exposed to 50 ppm or 100 ppm
trichloroethylene (Tri) by inhalation for 4 h. Blood and urine samples were taken at various …

Trichloroethylene (Tri) caused modest cytotoxicity in freshly isolated human proximal tubular
(hPT) cells, as assessed by significant decreases in lactate dehydrogenase (LDH) activity …

Renal cell carcinomas (RCC) develop as a consequence of somatic mutations of the von
Hippel-Lindau (VHL) tumour suppressor gene. Recent epidemiological studies show that …

Aims: To investigate the nephrotoxic potential of trichloroethylene in a currently exposed
population using sensitive urinary markers of kidney toxicity. Methods: Renal dysfunction …

The toxicity and metabolism of trichloroethylene (TRI) were studied in renal proximal tubular
(PT) and distal tubular (DT) cells from male Fischer 344 rats. TRI was slightly toxic to both PT …

Several haloalkenes are metabolized in part to nephrotoxic cysteine S-conjugates; for
example, trichloroethylene and tetrafluoroethylene are converted to S-(1, 2-dichlorovinyl)-l …

Objectives To describe past practice in meta-analyses found in occupational epidemiology,
identifying the major issues that should be considered by researchers planning a meta …