Abstract Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …

Alzheimer's disease (AD) is a neurodegenerative disease with unknown pathogenesis and
complex pathological manifestations. At present, a large number of studies on targeted …

Abstract Background Nuclear acetyl-CoA pools govern histone acetylation that controls
synaptic plasticity and contributes to cognitive deterioration in patients with Alzheimer's …

Understanding the underlying mechanisms of memory formation and maintenance has been
a major goal in the field of neuroscience. Memory formation and maintenance are tightly …

Epigenetic modifications such as histone methylation permit change in chromatin structure
without accompanying change in the underlying genomic sequence. A number of studies in …

In the past few decades, the field of neuroepigenetics has investigated how the brain
encodes information to form long-lasting memories that lead to stable changes in behaviour …

Heterozygous mutations in KMT2B are associated with an early-onset, progressive and
often complex dystonia (DYT28). Key characteristics of typical disease include focal motor …

Epigenetic dysregulation, which leads to the alteration of gene expression in the brain, is
suggested as one of the key pathophysiological bases of ageing and neurodegeneration …

Early-onset generalized dystonia represents the severest form of dystonia, a hyperkinetic
movement disorder defined by involuntary twisting postures. Although frequently transmitted …

Alzheimer's disease (AD) is the major cause of dementia in Western societies. It progresses
asymptomatically during decades before being belatedly diagnosed when therapeutic …