This review provides the reader a concise overview of the majority of prodrug approaches
with the emphasis on the modern approaches to prodrug design. The chemical approach …

Undesirable taste is an important problem for patient compliance. Several oral
pharmaceuticals and bulking agents have disagreeable and bitter-tasting components. The …

It is believed that the bitter taste of paracetamol, a pain killer drug, is due to its hydroxyl
group. Hence, it is expected that blocking the hydroxy group with a suitable linker could …

DFT calculations for the acid-catalyzed hydrolysis of several maleamic acid amide
derivatives revealed that the reaction rate-limiting step is determined on the nature of the …

Introduction: The revolution in computational chemistry greatly impacted the drug design
and delivery fields, in general, and recently the utilization of the prodrug approach in …

The present study included the use of the approximate semi-experimental method, the time-
independent density function theory (unrestricted), the timedependent density function …

The goal of this project was to design novel dopamine prodrugs for the treatment of
Parkinson's disease that can improve the overall biopharmaceutical profile of the current …

Density functional theory calculation results demonstrated that the efficiency of the acid‐
catalyzed hydrolysis of Kirby's acid amides 1–15 is strongly dependent on the substitution …

Based on stability studies on the drugs atenolol and propranolol and some of their
derivatives it is believed that increasing the lipophilicity of the drug will lead to an increase in …

The palatability of the active ingredient of a drug is a significant obstacle in developing a
patient friendly dosage form. Organoleptic properties, such as taste, are an important factor …