Prosthetic Joint Infection (PJI) causes significant morbidity and mortality for patients globally.
Delivery of antibiotics to the site of infection has potential to improve the treatment outcomes …

Strategies to manipulate immune cell co-inhibitory or co-activating signals have
revolutionized immunotherapy. However, certain immunologically cold diseases, such as …

Aims Biofilm-related infection is a major complication that occurs in orthopaedic surgery.
Various treatments are available but efficacy to eradicate infections varies significantly. A …

Fracture-related infection (FRI) is a devastating complication in orthopedic surgery. A recent
study showed that FRI causes more severe infection and further delays healing in …

Infected osteolysis as a common secondary osteoporosis is associated with excessive
osteoclastogenesis and bone resorption. The inhibition of osteoclastogenesis and bone …

Aims Gram-negative periprosthetic joint infection (PJI) has been poorly studied despite its
rapidly increasing incidence. Treatment with one-stage revision using intra-articular (IA) …

Background: Vancomycin-soaked autograft application in anterior cruciate ligament
reconstruction (ACLR) significantly reduces postoperative infection rates. However, the …

Although intra-articular vancomycin powder (VP) is sometimes applied before the closure of
the incision to prevent periprosthetic joint infection (PJI) after joint replacement, the dosage …

The biofilm-induced “relatively immune-compromised zone” creates an immunosuppressive
microenvironment that is a significant contributor to refractory infections in orthopedic …

Background Systemic vancomycin administration pre-operatively for the infection
prophylaxis of spinal implant surgery remains unsatisfactory. This study aimed to explore the …