Synthesis and Biological Evaluation of New Schiff Bases Derived from 4-Amino-5-(3-fluorophenyl)-1, 2, 4-triazole-3-thione

S Janowska, D Khylyuk, M Janowski, U Kosikowska… - Molecules, 2023 - mdpi.com
The treatment of infectious diseases is a challenging issue faced by the medical community.
The emergence of drug-resistant strains of bacteria and fungi is a major concern …

Synthesis, Molecular Docking Study, and Biological Evaluation of New 4-(2,5-Dimethyl-1H-pyrrol-1-yl)-N'-(2-(substituted)acetyl)benzohydrazides as Dual Enoyl ACP …

MH Mahnashi, P Koganole, SS Ashgar, IA Shaikh… - Antibiotics, 2023 - mdpi.com
In this study, a new series of 4-(2, 5-dimethyl-1 H-pyrrol-1-yl)-N′-(2-(substituted) acetyl)
benzohydrazides (5a–n) were prepared and new heterocycles underwent thorough …

Identification of Novel Compounds Inhibiting the Kinase Activity of the CDK5/p25 Complex via Direct Binding to p25

R Jabeur, C Corbel, P Loyer, A Le Parc, A Le Grand… - Biochemistry, 2023 - ACS Publications
Tamoxifen, the gold standard drug for endocrine therapy for breast cancer, modulates the
phosphorylation status of the TAU protein in Alzheimer's disease by inhibiting CDK5 kinase …

Unveiling Resistance and Virulence Mechanisms under Darwinian Positive Selection for Novel Drug Discovery for Gardnerella vaginalis.

EG Sousa, AG Felice, FV Dominici… - Venereology (2674 …, 2024 - search.ebscohost.com
Gardnerella vaginalis is a Gram-variable bacillus capable of causing bacterial vaginosis, a
condition prevalent in reproductive-age women, this bacterium is present in almost 100% of …