The role of dopamine in the control of movement is traditionally associated with ascending
projections to the basal ganglia. However, more recently descending dopaminergic …

The mesencephalic locomotor region (MLR) was discovered several decades ago in the cat.
It was functionally defined based on the ability of low threshold electrical stimuli within a …

Locomotor function, mediated by lumbar neural circuitry, is modulated by descending spinal
pathways. Spinal cord injury (SCI) interrupts descending projections and denervates lumbar …

Motor learning is a core aspect of human life and appears to be ubiquitous throughout the
animal kingdom. Dopamine, a neuromodulator with a multifaceted role in synaptic plasticity …

During the last 50 years, the serotonergic (5-HT) system was reported to exert a complex
modulation of locomotor activity. Here, we focus on two key factors that likely contribute to …

Co‐transmission of glutamate by brain dopaminergic (DA) neurons was recently proposed
as a potential factor influencing cell survival in models of Parkinson's disease. Intriguingly …

Astrocytes, the most abundant glial cells in the central nervous system, respond to a wide
variety of neurotransmitters binding to metabotropic receptors. Here, we investigated the …

Nucleus incertus (NI) is a brainstem structure involved in the control of arousal, stress
responses and locomotor activity. It was reported recently that NI neurons express the …

Meso-diencephalic dopaminergic neurons are known to modulate locomotor behaviors
through their ascending projections to the basal ganglia, which in turn project to the …

Recent work demonstrated that activation of spinal D1 and D5 dopamine receptors
(D1/D5Rs) facilitates non-Hebbian long-term potentiation (LTP) at primary afferent synapses …