Primary cilia are specialized sensory organelles that protrude from the apical surface of most
cell types. Over the past two decades, they have been found to play important roles in tissue …

In recent decades, cancer stem cells (CSCs) have been increasingly identified in many
malignancies. CSC-related signaling pathways and their functions provide new strategies …

Renal ciliopathies are a group of disorders characterised by nephronophthisis, cystic
kidneys or renal cystic dysplasia whose underlying disease pathogenesis is related to …

ARPKD is a genetically inherited kidney disease that manifests by bilateral enlargement of
cystic kidneys and liver fibrosis. It shows a range of severity, with 30% of individuals dying …

Chronic kidney disease (CKD) encompasses a group of diverse diseases that are
associated with accumulating kidney damage and a decline in glomerular filtration rate …

The autosomal recessive disorder Ataxia-Telangiectasia is caused by a dysfunction of the
stress response protein, ATM. In the nucleus of proliferating cells, ATM senses DNA double …

Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive
polycystic kidney disease (ARPKD) are characterized by bilateral cystic kidney disease …

Polycystic Kidney Disease (PKD) refers to a group of disorders, driven by the formation of
cysts in renal tubular cells and is currently one of the leading causes of end-stage renal …

Background Being amongst the leading factors of death and distress, chronic kidney
disease (CKD) has affected around 850 million people globally. The Wnt/β‐catenin axis is …

The orientation of cells in two-dimensional and three-dimensional space underpins how the
kidney develops and responds to disease. The process by which cells orientate themselves …