Interoception plays an important role in homeostatic regulation of energy intake and
metabolism. Major interoceptive pathways include gut-to-brain and adipose tissue-to brain …

There are key differences between the central nervous system (CNS)(brain and spinal cord)
and peripheral nervous system (PNS), such as glial cell types, whether there is protection by …

The peripheral nervous system plays an important role in cancer progression. Studies in
multiple cancer types have shown that higher intratumoral nerve density is associated with …

The preservation of pancreatic islet β-cells is crucial in diabetes mellitus, encompassing
both type 1 and type 2 diabetes. β-cell dysfunction, reduced mass, and apoptosis are central …

In pancreatic cancer, significant alterations occur in the local nervous system, including
axonogenesis, neural remodeling, perineural invasion, and perineural neuritis. Pancreatic …

Background The autonomic nervous system is frequently affected in some
neurodegenerative diseases, including Parkinson's disease and Dementia with Lewy …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant tumor with a high
metastatic potential. Perineural invasion (PNI) occurs in the early stages of PDAC with a …

Abstract β cells are the main cells responsible for the hypoglycemic function of pancreatic
islets, and the insulin secreted by these cells is the only hormone that lowers blood glucose …

The pancreas exerts endocrine and exocrine functions in energy balance. The neural
innervation and immune milieu are both crucial in supporting pancreatic homeostasis. The …

Proper functioning of the digestive system is ensured by coordinated action of the central
and peripheral nervous systems (PNS). Peripheral innervation of the digestive system can …