The human obesity gene map: the 2005 update

T Rankinen, A Zuberi, YC Chagnon, SJ Weisnagel… - …, 2006 - Wiley Online Library
This paper presents the 12th update of the human obesity gene map, which incorporates
published results up to the end of October 2005. Evidence from single‐gene mutation …

Mammographic breast density as an intermediate phenotype for breast cancer

NF Boyd, JM Rommens, K Vogt, V Lee… - The lancet …, 2005 - thelancet.com
The amount of radiologically dense breast-tissue appearing on a mammogram varies
between women because of differences in the composition of breast tissue, and is referred …

Genetic epidemiology of obesity

W Yang, T Kelly, J He - Epidemiologic reviews, 2007 - academic.oup.com
Obesity has become a global epidemic and contributes to the increasing burden of type 2
diabetes, cardiovascular disease, stroke, some types of cancer, and premature death …

Genomewide scans of complex human diseases: true linkage is hard to find

J Altmüller, LJ Palmer, G Fischer, H Scherb… - The American Journal of …, 2001 - cell.com
Many" complex" human diseases, which involve multiple genetic and environmental
determinants, have increased in incidence during the past 2 decades. During the same time …

The evolution of β‐cell dysfunction and insulin resistance in type 2 diabetes

RN Bergman, DT Finegood… - European journal of …, 2002 - Wiley Online Library
Insulin resistance and β‐cell dysfunction have important roles in the pathogenesis and
evolution of type 2 diabetes. The development of precise methods to measure these factors …

Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)

P Pajukanta, HE Lilja, JS Sinsheimer, RM Cantor… - Nature …, 2004 - nature.com
Familial combined hyperlipidemia (FCHL), characterized by elevated levels of serum total
cholesterol, triglycerides or both,, is observed in about 20% of individuals with premature …

The human obesity gene map: the 2004 update

L Pérusse, T Rankinen, A Zuberi, YC Chagnon… - Obesity …, 2005 - Wiley Online Library
This paper presents the eleventh update of the human obesity gene map, which
incorporates published results up to the end of October 2004. Evidence from single‐gene …

The genetic landscape of type 2 diabetes in mice

SM Clee, AD Attie - Endocrine reviews, 2007 - academic.oup.com
Inbred mouse strains provide genetic diversity comparable to that of the human population.
Like humans, mice have a wide range of diabetes-related phenotypes. The inbred mouse …

The dysmetabolic syndrome

L Groop, M Orho‐Melander - Journal of internal medicine, 2001 - Wiley Online Library
Groop L, Orho‐Melander M (Wallenberg Laboratory, Lund University, Malmö, Sweden). The
dysmetabolic syndrome. J Intern Med 2001; 250: 105–120. The first unifying definition for the …

Genetics of type 2 diabetes

I Barroso - Diabetic medicine, 2005 - Wiley Online Library
Abstract Type 2 diabetes (T2D) has become a health‐care problem worldwide, with the rise
in disease prevalence being all the more worrying as it not only affects the developed world …