Targeting cell cycle regulators in hematologic malignancies

E Aleem, RJ Arceci - Frontiers in cell and developmental biology, 2015 - frontiersin.org
Hematologic malignancies represent the fourth most frequently diagnosed cancer in
economically developed countries. In hematologic malignancies normal hematopoiesis is …

Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells

S Glennie, I Soeiro, PJ Dyson, EWF Lam, F Dazzi - Blood, 2005 - ashpublications.org
It has been shown that mesenchymal stem cells (MSCs) induce T cells to become
unresponsive. We characterized the phenotype of these T cells by dissecting the effect of …

Roles of B‐1 and B‐2 cells in innate and acquired IgA‐mediated immunity

K Suzuki, M Maruya, S Kawamoto… - Immunological …, 2010 - Wiley Online Library
The gut harbors an extremely dense and complex community of microorganisms that are in
constant dialog with our immune cells. The gut bacteria provide strong selective pressure to …

FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism

SF de Mattos, A Essafi, I Soeiro… - … and cellular biology, 2004 - Am Soc Microbiol
Cell cycle arrest by FoxO transcription factors involves transcriptional repression of cyclin D,
although the exact mechanism remains unclear. In this study, we used the BCR-ABL …

A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice

JC Poe, V Minard-Colin, EI Kountikov… - The Journal of …, 2012 - journals.aai.org
Malignant B cells responding to external stimuli are likely to gain a growth advantage in vivo.
These cells may therefore maintain surface CD19 expression to amplify transmembrane …

Survival response to B-cell receptor ligation is restricted to progressive chronic lymphocytic leukemia cells irrespective of Zap70 expression

PA Deglesne, N Chevallier, R Letestu… - Cancer research, 2006 - AACR
Despite very similar gene expression profiles, the clinical course of B-cell chronic
lymphocytic leukemia (B-CLL) is heterogeneous. Immunoglobulin VH (IgVH) mutational …

Cyclin D3 is selectively required for proliferative expansion of germinal center B cells

MH Cato, SK Chintalapati, IW Yau… - … and cellular biology, 2011 - Taylor & Francis
The generation of robust T-cell-dependent humoral immune responses requires the
formation and expansion of germinal center structures within the follicular regions of the …

GSK3β mediates suppression of cyclin D2 expression by tumor suppressor PTEN

W Huang, HY Chang, T Fei, H Wu, YG Chen - Oncogene, 2007 - nature.com
PTEN, encoding a lipid phosphatase, is a tumor suppressor gene and is mutated in various
types of cancers. It is reported to regulate G1 to S phase transition of the cell cycle by …

[HTML][HTML] De novo CD5+ diffuse large B-cell lymphoma: biology, mechanism, and treatment advances

Y Xu, W Sun, F Li - Clinical Lymphoma Myeloma and Leukemia, 2020 - Elsevier
Despite its low frequency in all variants of diffuse large B-cell lymphoma (DLBCL), CD5+
DLBCL has gradually gained the attention it deserves, the result of its poorer outcomes …

Regulation and function of cyclin D2 in B lymphocyte subsets

TC Chiles - The Journal of Immunology, 2004 - journals.aai.org
Abs produced by B lymphocytes play an essential role in humoral immunity against
pathogens. This response is dependent upon the extent of genome replication, which in turn …