[HTML][HTML] The effect of pegcetacoplan treatment on photoreceptor maintenance in geographic atrophy monitored by artificial intelligence–based OCT analysis

S Riedl, WD Vogl, J Mai, GS Reiter, D Lachinov… - Ophthalmology …, 2022 - Elsevier
Purpose To investigate the therapeutic effect of intravitreal pegcetacoplan on the inhibition
of photoreceptor (PR) loss and thinning in geographic atrophy (GA) on conventional spectral …

Onset and progression of persistent choroidal hypertransmission defects in intermediate age-related macular degeneration: a novel clinical trial endpoint

J Liu, M Shen, R Laiginhas, G Herrera, J Li… - American Journal of …, 2023 - Elsevier
Purpose The appearance and growth of persistent choroidal hypertransmission defects
(hyperTDs) detected on en face swept-source optical coherence tomography (SS-OCT) …

Comparison between B-scan and en face images for incomplete and complete retinal pigment epithelium and outer retinal atrophy

F Corvi, G Corradetti, R Laiginhas, J Liu, G Gregori… - Ophthalmology …, 2023 - Elsevier
Purpose To evaluate and compare the detection of incomplete retinal pigment epithelium
and outer retinal atrophy (iRORA) and complete retinal pigment epithelium and outer retinal …

Depth-resolved visualization and automated quantification of hyperreflective foci on OCT scans using optical attenuation coefficients

H Zhou, J Liu, R Laiginhas, Q Zhang… - Biomedical optics …, 2022 - opg.optica.org
An automated depth-resolved algorithm using optical attenuation coefficients (OACs) was
developed to visualize, localize, and quantify hyperreflective foci (HRF) seen on OCT …

Progression rate of macular retinal pigment epithelium atrophy in geographic atrophy and selected inherited retinal dystrophies. A systematic review and meta …

FL Bassil, JM Colijn, AAHJ Thiadens… - American Journal of …, 2024 - Elsevier
Purpose To compare the macular retinal pigment epithelium (RPE) atrophy progression rate
of selected degenerative and macular inherited retinal diseases (IRD). Design Systematic …

Identifying geographic atrophy

L Clevenger, A Rachitskaya - Current Opinion in Ophthalmology, 2023 - journals.lww.com
Identification of GA and of risk factors for GA development or progression is essential when
counseling AMD patients and discussing prognosis. With new therapies on the horizon for …

[HTML][HTML] Quantitative comparison of automated OCT and conventional FAF-based geographic atrophy measurements in the phase 3 OAKS/DERBY trials

J Mai, GS Reiter, S Riedl, WD Vogl, A Sadeghipour… - Scientific Reports, 2024 - nature.com
With the approval of the first two substances for the treatment of geographic atrophy (GA)
secondary to age-related macular degeneration (AMD), a standardized monitoring of …

Deep-learning automated quantification of longitudinal OCT scans demonstrates reduced RPE loss rate, preservation of intact macular area and predictive value of …

DJ Fu, S Glinton, V Lipkova, L Faes, B Liefers… - British Journal of …, 2024 - bjo.bmj.com
Objective To evaluate the role of automated optical coherence tomography (OCT)
segmentation, using a validated deep-learning model, for assessing the effect of C3 …

[HTML][HTML] Comparison between Spectral-Domain and Swept-Source OCT Angiography for the Measurement of Persistent Hypertransmission Defects in Age-Related …

G Herrera, M Shen, O Trivizki, J Liu, Y Shi, FE Hiya… - Ophthalmology …, 2025 - Elsevier
Purpose Spectral-domain OCT angiography (SD-OCTA) scans were tested in an algorithm
developed for use with swept-source OCT angiography (SS-OCTA) scans to determine if SD …

[HTML][HTML] Visual Sensitivity Loss in Geographic Atrophy: Structure–Function Evaluation Using Defect-Mapping Microperimetry

Z Wu, X Hadoux, M Jannaud, EK Glover… - … & Visual Science, 2024 - iovs.arvojournals.org
Purpose: To examine the structure–function relationship in eyes with geographic atrophy
(GA) using defect-mapping microperimetry, a testing strategy optimized to quantify the …