Aptamer-based detection of circulating targets for precision medicine

L Wu, Y Wang, X Xu, Y Liu, B Lin, M Zhang… - Chemical …, 2021 - ACS Publications
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

[HTML][HTML] Current perspectives on aptamers as diagnostic tools and therapeutic agents

P Kumar Kulabhusan, B Hussain, M Yüce - Pharmaceutics, 2020 - mdpi.com
Aptamers are synthetic single-stranded DNA or RNA sequences selected from combinatorial
oligonucleotide libraries through the well-known in vitro selection and iteration process …

Advanced nanomaterials as sample technique for bio-analysis

N Sun, H Yu, H Wu, X Shen, C Deng - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
The biological compositions including cells, proteins/peptides, nucleic acids, extracellular
vesicles (EVs) and metabolites are no doubt closely related to almost all physiological and …

Aptamers as diagnostic tools in cancer

D Ruiz Ciancio, MR Vargas, WH Thiel, MA Bruno… - Pharmaceuticals, 2018 - mdpi.com
Cancer is the second leading cause of death worldwide. Researchers have been working
hard on investigating not only improved therapeutics but also on early detection methods …

Gold Nanoparticle-Based Microfluidic Chips for Capture and Detection of Circulating Tumor Cells

VA Pedrosa, K Chen, TJ George, ZH Fan - Biosensors, 2023 - mdpi.com
Liquid biopsy has progressed to its current use to diagnose and monitor cancer. Despite the
recent advances in investigating cancer detection and diagnosis strategies, there is still a …

Incorporation of lateral microfiltration with immunoaffinity for enhancing the capture efficiency of rare cells

K Chen, J Amontree, J Varillas, J Zhang, TJ George… - Scientific reports, 2020 - nature.com
The methods for isolating rare cells such as circulating tumor cells (CTCs) can be generally
classified into two categories: those based on physical properties (eg, size) and methods …

Micro-magnetofluidic system for rare cell analysis: from principle to translation

K Chen, Z Wang - Chemosensors, 2023 - mdpi.com
Rare cells play essential roles in the initiation and progression of diseases and therefore
their analysis is of great interest. The micro-magnetofluidic system is one of the emerging …

The potential of aptamers for cancer research

Z Zhou, M Liu, J Jiang - Analytical biochemistry, 2018 - Elsevier
Aptamers are promising alternatives to antibodies and can be used as high affinity agents
for the cancer detection and the targeted drug transportation. In this manuscript, we highlight …

A high-throughput microfluidic magnetic separation (µFMS) platform for water quality monitoring

KY Castillo-Torres, ES McLamore, DP Arnold - Micromachines, 2019 - mdpi.com
The long-term aim of this work is to develop a biosensing system that rapidly detects
bacterial targets of interest, such as Escherichia coli, in drinking and recreational water …

Immunomagnetic separation of circulating tumor cells with microfluidic chips and their clinical applications

H Chen, Y Li, Z Zhang, S Wang - Biomicrofluidics, 2020 - pubs.aip.org
Circulating tumor cells (CTCs) are tumor cells detached from the original lesion and getting
into the blood and lymphatic circulation systems. They potentially establish new tumors in …