Cancer has long been viewed as a disease of normal development gone awry. Cancer stem-
like cells (CSCs), also termed as tumor-initiating cells (TICs), are increasingly recognized as …

The insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) plays essential roles in
embryogenesis and carcinogenesis. IGF2BP1 serves as a post-transcriptional fine-tuner …

The tumor microenvironment is abundant with exosomes that are secreted by the cancer
cells themselves. Exosomes are nanosized, organelle-like membranous structures that are …

Chronic inflammation is a highly prevalent consequence of changes in environmental and
lifestyle factors that contribute to the development of cancer. The basis for this critical …

Purpose: Chemoresistance is the main cause of treatment failure in cancer and is
associated with distant metastases and epithelial-to-mesenchymal transition (EMT). This …

The let-7 family is among the first microRNAs found. Recent investigations have indicated
that it is highly expressed in many systems, including cerebral and cardiovascular systems …

Background This study aimed to explore the effects of HMGA 2 on cell proliferation and
metastases in lung cancer and its underlying mechanism. Methods HMGA 2 expression in …

Simple Summary PDAC is one of the most malignant tumors and its treatment, whether
surgery or chemotherapy, has shown poor results. Resistance to gemcitabine and other …

The MUC1 gene evolved in mammalian species to provide protection of epithelia. The
transmembrane MUC1 C-terminal subunit (MUC1-C) signals stress to the interior of the …

The abnormal regulation and expression of microRNA (miRNA) are closely related to the
aging process and the occurrence and development of aging-related diseases. Lethal-7 (let …