As platelets aggregate and activate at the site of vascular injury to stem bleeding, they are
subjected to a myriad of biochemical and biophysical signals and cues. As clot formation …

Although platelets and the coagulation factors are components of the blood system, they
become part of and contribute to the tumor microenvironment (TME) not only within a solid …

Implantation of biomaterials and medical devices in the body triggers the foreign body
reaction (FBR) which is characterized by macrophage fusion at the implant surface leading …

The human glycoprotein (GP) IIb/IIIa belongs to a large family of cation-dependent adhesion
molecules known as integrins, which share a common heterodimeric structure. The primary …

Fibrinogen adsorption on a surface results in the modification of its functional characteristics.
Our previous studies revealed that fibrinogen adsorbs onto surfaces essentially in 2 different …

В соответствии с «М1/М2» парадигмой выделяют два подтипа активированных
макрофагов классически активированные (М1) и альтернативно активированные (М2) …

Adsorption of fibrinogen on the luminal surface of biomaterials is a critical early event during
the interaction of blood with implanted vascular graft prostheses which determines their …

Integrin tensions are critical for cell mechanotransduction. By converting force to
fluorescence, molecular tension sensors image integrin tensions in live cells with a high …

The regulated ability of integrin αIIbβ3 to bind fibrinogen plays a crucial role in platelet
aggregation, adhesion, and hemostasis. Employing an optical-trap-based electronic force …

Integrin α2β1–mediated adhesion of human platelets to monomeric type I collagen or to the
GFOGER peptide caused a time-dependent activation of PI3K and Akt phosphorylation. This …