Histone lysine methylation has emerged as a critical player in the regulation of gene
expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a …

Transposable elements (TEs) are genomic parasites that selfishly replicate at the expense of
host fitness. Fifty years of evolutionary studies of TEs have concentrated on the deleterious …

By the onset of morphogenesis, Drosophila embryos consist of about 6000 cells that express
distinct gene combinations. Here, we used single-cell sequencing of precisely staged …

Drosophila melanogaster plays an important role in molecular, genetic, and genomic studies
of heredity, development, metabolism, behavior, and human disease. The initial reference …

Genome function is dynamically regulated in part by chromatin, which consists of the
histones, non-histone proteins and RNA molecules that package DNA. Studies in …

Chromatin is composed of DNA and a variety of modified histones and non-histone proteins,
which have an impact on cell differentiation, gene regulation and other key cellular …

Post‐translational modification of histones and DNA methylation are important components
of chromatin‐level control of genome activity in eukaryotes. However, principles governing …

Chromatin modifications are associated with many aspects of gene expression, yet their role
in cellular transitions during development remains elusive. Here, we use a new approach to …

Heterochromatin mostly comprises repeated sequences prone to harmful ectopic
recombination during double-strand break (DSB) repair. In Drosophila …

Position-effect variegation (PEV) results when a gene normally in euchromatin is juxtaposed
with heterochromatin by rearrangement or transposition. When heterochromatin packaging …