Cytokines: can cancer get the message?

RM Morris, TO Mortimer, KL O'Neill - Cancers, 2022 - mdpi.com
Simple Summary Cytokines are important molecular players in cancer development,
progression, and potential targets for treatment. Despite being small and overlooked …

Progress in regenerative medicine: exploring autologous platelet concentrates and their clinical applications

L Giannotti, B Di Chiara Stanca, F Spedicato, P Nitti… - Genes, 2023 - mdpi.com
The goal of regenerative medicine is to achieve tissue regeneration. In the past, commonly
used techniques included autologous or allogeneic transplantation and stem cell therapy …

Angiogenesis in lung cancer: understanding the roles of growth factors

TYS Ngaha, AV Zhilenkova, FE Essogmo, IK Uchendu… - Cancers, 2023 - mdpi.com
Simple Summary Growth factors promote angiogenesis, which is a critical process in the
development of tumors. One of the therapeutic techniques being investigated in the …

Implications of pregnancy on cardiometabolic disease risk: preeclampsia and gestational diabetes

M Elgazzaz, PC Woodham, J Maher… - American Journal of …, 2024 - journals.physiology.org
Cardiometabolic disorders, such as obesity, insulin resistance, and hypertension, prior to
and within pregnancy are increasing in prevalence worldwide. Pregnancy-associated …

Tumor biomarkers for diagnosis, prognosis and targeted therapy

Y Zhou, L Tao, J Qiu, J Xu, X Yang, Y Zhang… - … and Targeted Therapy, 2024 - nature.com
Tumor biomarkers, the substances which are produced by tumors or the body's responses to
tumors during tumorigenesis and progression, have been demonstrated to possess critical …

Rationale, in silico docking, ADMET profile, design, synthesis and cytotoxicity evaluations of phthalazine derivatives as VEGFR-2 inhibitors and apoptosis inducers

HH Bayoumi, MK Ibrahim, MA Dahab, F Khedr… - RSC …, 2024 - pubs.rsc.org
New phthalazine derivatives as vascular endothelial growth factor receptor-2 (VEGFR-2)
inhibitors were synthesized joined to different spacers including pyrazole, α, β-unsaturated …

Dimer peptide ligands of vascular endothelial growth factor: optimizing linker length for high affinity and antiangiogenic activity

X Ye, JF Gaucher, H Hu, L Wang… - Journal of Medicinal …, 2023 - ACS Publications
Macromolecular ligands targeting vascular endothelial growth factor A (VEGF) to inhibit
pathological angiogenesis are used in the clinic for the treatment of cancers and ocular …

Towards a unified approach in autoimmune fibrotic signalling pathways

M Sisto, S Lisi - International Journal of Molecular Sciences, 2023 - mdpi.com
Autoimmunity is a chronic process resulting in inflammation, tissue damage, and
subsequent tissue remodelling and organ fibrosis. In contrast to acute inflammatory …

[HTML][HTML] Vascular Endothelial Growth Factor (VEGF) Family and the Immune System: Activators or Inhibitors?

CM Failla, ML Carbone, C Ramondino, E Bruni… - Biomedicines, 2024 - mdpi.com
The vascular endothelial growth factor (VEGF) family includes key mediators of
vasculogenesis and angiogenesis. VEGFs are secreted by various cells of epithelial and …

Decoding the synergistic potential of MAZ‐51 and zingerone as therapy for melanoma treatment in alignment with sustainable development goals

K Letsoalo, E Nortje, S Patrick… - Cell Biochemistry …, 2024 - Wiley Online Library
Melanoma, an invasive class of skin cancer, originates from mutations in melanocytes, the
pigment‐producing cells. Globally, approximately 132,000 new cases are reported each …