J Scekic‐Zahirovic, O Sendscheid, H El Oussini… - The EMBO …, 2016 - embopress.org
FUS is an RNA‐binding protein involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS‐containing aggregates are often …
Background: The differential susceptibly hypothesis suggests that certain genetic variants moderate the effects of both negative and positive environments on mental health and may …
B Negrutskii, D Vlasenko, A El'skaya - Expert Review of …, 2012 - Taylor & Francis
Phosphoproteomics is often aimed at deciphering the modified components of signaling pathways in certain organisms, tissues and pathologies. Phosphorylation of housekeeping …
X Wang, M Han, S Wang, Y Sun, W Zhao, Z Xue… - Theranostics, 2022 - ncbi.nlm.nih.gov
Background: Splicing factors are essential for nascent pre-mRNA processing and critical in cancer progression, suggesting that proteins with splicing functions represent potential …
Activation of brown fat thermogenesis increases energy expenditure and alleviates obesity. Sympathetic nervous system (SNS) is important in brown/beige adipocyte thermogenesis …
Despite the success of therapies targeting oncogenes in cancer, clinical outcomes are limited by residual disease that ultimately results in relapse. This residual disease is often …
A Mitra, K Yoshida-Court, TN Solley, M Mikkelson… - Scientific reports, 2021 - nature.com
Ovarian cancer is associated with a high mortality rate due to diagnosis at advanced stages. Dissemination often occurs intraperitoneally within the ascites fluid. The microenvironment …
X Feng, D Ma, J Zhao, Y Song, Y Zhu, Q Zhou… - The EMBO …, 2020 - embopress.org
UHMK 1 is a nuclear serine/threonine kinase recently implicated in carcinogenesis. However, the functions and action mechanisms of UHMK 1 in the pathogenesis of human …
J Canet-Pons, NE Sen, A Arsović… - Neurobiology of …, 2021 - Elsevier
Large polyglutamine expansions in Ataxin-2 (ATXN2) cause multi-system nervous atrophy in Spinocerebellar Ataxia type 2 (SCA2). Intermediate size expansions carry a risk for selective …