Abstract Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …

Molecular similarity is a key concept in drug discovery. It is based on the assumption that
structurally similar molecules frequently have similar properties. Assessment of similarity …

Many questions about the biological activity and availability of small molecules remain
inaccessible to investigators who could most benefit from their answers. To narrow the gap …

Ebola virus causes sporadic outbreaks of lethal hemorrhagic fever in humans, but there is
no currently approved therapy. Cells take up Ebola virus by macropinocytosis, followed by …

Mammalian two-pore channel proteins (TPC1, TPC2; TPCN1, TPCN2) encode ion channels
in intracellular endosomes and lysosomes and were proposed to mediate endolysosomal …

Summary Presenilin 1 (PS1) deletion or Alzheimer's disease (AD)-linked mutations disrupt
lysosomal acidification and proteolysis, which inhibits autophagy. Here, we establish that …

Endosomes, lysosomes and lysosome-related organelles are emerging as important Ca2+
storage cellular compartments with a central role in intracellular Ca2+ signalling …

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a widespread and potent calcium-
mobilizing messenger that is highly unusual in activating calcium channels located on acidic …

Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause late-onset Parkinson's
disease, but its physiological function has remained largely unknown. Here we report that …

Abstract Changes in cytosolic free Ca 2+ concentration ([Ca 2+] c) play a crucial role in the
control of insulin secretion from the electrically excitable pancreatic β-cell. Secretion is …