Proteins are often described in textbooks as being only “marginally stable” but many
proteins, specifically those with a high free energy of unfolding are, in fact, so stable that they …

Super-selective multivalent ligand–receptor interactions display a signature step-like onset
in binding when meeting a characteristic density of target receptors. Materials engineered …

We used time-resolved Förster resonance energy transfer, circular dichroism, and molecular
dynamics simulation to investigate the structural dependence of synaptotagmin 1's …

Abstract Synaptotagmin-1 (syt1) functions as the Ca 2+-dependent sensor that triggers the
rapid and synchronous release of neurotransmitters from neurotransmitter-containing …

Synaptotagmin I (Syt I) is a vesicle-localized integral membrane protein that senses the
calcium ion (Ca2+) influx to trigger fast synchronous release of neurotransmitter. How the …

Diacylglycerol (DAG)-induced activation of phosphatidylinositol-phospholipase C (PI-PLC)
was studied with vesicles containing PI, either pure or in mixtures with dimyristoyl …

This thesis applied spectroscopy and molecular dynamics simulation to study the structural
biology of actin-binding domains (ABDs) from the spectrin superfamily of proteins as well as …

The signaling response of membrane modulated proteins are influenced by their complex
lipid environments. To further understand the mechanistic role of their signaling response …

Macroscopic characteristics of a peptide or protein are dependent on microscopic
properties. One microscopic property that has an effect on the macroscopic characteristics is …

Secondary structure of protein sequences is dependent on both internal and external
interactions of amino acid residues and ligand-binding partners. Internal residue features …