In this review we outline the unique effects of the autacoid adenosine in the kidney.
Adenosine is present in the cytosol of renal cells and in the extracellular space of normoxic …

In humans and experimental models of renal ischemia, tubular cells in various nephron
segments undergo necrotic and/or apoptotic cell death. Various factors, including nucleotide …

Background Volatile anesthetics protect against cardiac ischemia-reperfusion injury via
adenosine triphosphate-dependent potassium channel activation. The authors questioned …

Ischemic injury to the kidney is associated with high morbidity and mortality. Improving the
ability of the kidney to tolerate ischemic injury would have important implications. A …

Abstract The A 1, A 2A, A 2B and A 3 G-protein-coupled cell surface adenosine receptors
(ARs) are found to be upregulated in various tumor cells. Activation of the receptors by …

It was previously demonstrated that preischemic A 1 adenosine receptor (AR) activation
protects renal function after ischemia-reperfusion (IR) injury in rats. The role of the A 1 AR in …

Ischemic postconditioning (Postcond) is defined as rapid intermittent interruptions of blood
flow in the early phase of reperfusion and mechanically alters the hydrodynamics of …

Acute as well as delayed ischemic preconditioning (IPC) provides protection against cardiac
and neuronal ischemia reperfusion (IR) injury. This study determined whether delayed …

The autacoid, adenosine, is present in the normoxic kidney and generated in the cytosol as
well as at extracellular sites. The rate of adenosine formation is enhanced when the rate of …

Ischemic preconditioning (IPC) has a strong renoprotective effect during renal
ischemia/reperfusion (I/R) injury that is thought to relate to autophagy. However, the role of …