With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial
crystallography techniques for macromolecular structure determination have emerged …

Proteins guide the flows of information, energy, and matter that make life possible by
accelerating transport and chemical reactions, by allosterically modulating these reactions …

The binding and release of ligands from their protein targets is central to fundamental
biological processes as well as to drug discovery. Photopharmacology introduces chemical …

The Sample Environment and Characterization (SEC) group of the European X-ray Free-
Electron Laser (EuXFEL) develops sample delivery systems for the various scientific …

For decades, researchers have elucidated essential enzymatic functions on the atomic
length scale by tracing atomic positions in real-time. Our work builds on possibilities …

Structure-based drug design (SBDD) is a prominent method in rational drug development
and has traditionally benefitted from the atomic models of protein targets obtained using X …

After decades of diligent development at synchrotron light sources, the field of time-resolved
crystallography (TRX) is elevating to new heights. Driven by the appearance of X-ray free …

Enzymes with iron-containing active sites play crucial roles in catalysing a myriad of
oxidative reactions essential to aerobic life. Defining the three-dimensional structures of iron …

NendoU from SARS-CoV-2 is responsible for the virus's ability to evade the innate immune
system by cleaving the polyuridine leader sequence of antisense viral RNA. Here we report …

Serial crystallography, born from groundbreaking experiments at the Linac Coherent Light
Source in 2009, has evolved into a pivotal technique in structural biology. Initially pioneered …