The Type VI secretion system: a versatile bacterial weapon

S Coulthurst - Microbiology, 2019 - microbiologyresearch.org
The Type VI secretion system (T6SS) is a protein nanomachine that is widespread in Gram-
negative bacteria and is used to translocate effector proteins directly into neighbouring cells …

An overview of anti-eukaryotic T6SS effectors

J Monjarás Feria, MA Valvano - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
The type VI secretion system (T6SS) is a transmembrane multiprotein nanomachine
employed by many Gram-negative bacterial species to translocate, in a contact-dependent …

Structure and activity of the type VI secretion system

Y Cherrak, N Flaugnatti, E Durand, L Journet… - Microbiology …, 2019 - Am Soc Microbiol
The type VI secretion system (T6SS) is a multiprotein machine that uses a spring-like
mechanism to inject effectors into target cells. The injection apparatus is composed of a …

Contact-dependent interbacterial antagonism mediated by protein secretion machines

TA Klein, S Ahmad, JC Whitney - Trends in microbiology, 2020 - cell.com
To establish and maintain an ecological niche, bacteria employ a wide range of pathways to
inhibit the growth of their microbial competitors. Some of these pathways, such as those that …

Evolution of Salmonella-Host Cell Interactions through a Dynamic Bacterial Genome

B Ilyas, CN Tsai, BK Coombes - Frontiers in cellular and infection …, 2017 - frontiersin.org
Salmonella Typhimurium has a broad arsenal of genes that are tightly regulated and
coordinated to facilitate adaptation to the various host environments it colonizes. The …

A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria

JC Whitney, SB Peterson, J Kim, M Pazos, AJ Verster… - Elife, 2017 - elifesciences.org
The Firmicutes are a phylum of bacteria that dominate numerous polymicrobial habitats of
importance to human health and industry. Although these communities are often densely …

A novel stabilization mechanism for the type VI secretion system sheath

P Bernal, RCD Furniss, S Fecht… - Proceedings of the …, 2021 - National Acad Sciences
The type VI secretion system (T6SS) is a phage-derived contractile nanomachine primarily
involved in interbacterial competition. Its pivotal component, TssA, is indispensable for the …

Bacterial type VI secretion system (T6SS): an evolved molecular weapon with diverse functionality

RP Singh, K Kumari - Biotechnology letters, 2023 - Springer
Bacterial secretion systems are nanomolecular complexes that release a diverse set of
virulence factors/or proteins into its surrounding or translocate to their target host cells …

The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella

J Ziveri, F Tros, IC Guerrera, C Chhuon, M Audry… - Nature …, 2017 - nature.com
The enzyme fructose-bisphosphate aldolase occupies a central position in glycolysis and
gluconeogenesis pathways. Beyond its housekeeping role in metabolism, fructose …

Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape

M Brodmann, RF Dreier, P Broz, M Basler - Nature communications, 2017 - nature.com
Francisella tularensis is an intracellular pathogen that causes the fatal zoonotic disease
tularaemia. Critical for its pathogenesis is the ability of the phagocytosed bacteria to escape …