[HTML][HTML] Targeted treatment of head and neck (pre) cancer: preclinical target identification and development of novel therapeutic applications
AM van Harten, RH Brakenhoff - Cancers, 2021 - mdpi.com
Head and neck squamous cell carcinomas (HNSCC) develop in the mucosal lining of the
upper-aerodigestive tract. In carcinogen-induced HNSCC, tumors emerge from …
upper-aerodigestive tract. In carcinogen-induced HNSCC, tumors emerge from …
Cancer progression gene expression profiling identifies the urokinase plasminogen activator receptor as a biomarker of metastasis in cutaneous squamous cell …
Cutaneous squamous cell carcinoma (cSCC) of the head and neck region is the second
most prevalent skin cancer, with metastases to regional lymph nodes occurring in 2%–5% of …
most prevalent skin cancer, with metastases to regional lymph nodes occurring in 2%–5% of …
Beta human papillomavirus 8 E6 induces micronucleus formation and promotes chromothripsis
D Dacus, S Stancic, SR Pollina, E Rifrogiate… - Journal of …, 2022 - Am Soc Microbiol
Cutaneous beta genus human papillomaviruses (β-HPVs) are suspected to promote the
development of nonmelanoma skin cancer (NMSC) by destabilizing the host genome …
development of nonmelanoma skin cancer (NMSC) by destabilizing the host genome …
Whole genome analysis reveals the genomic complexity in metastatic cutaneous squamous cell carcinoma
Metastatic cutaneous squamous cell carcinoma (CSCC) is a highly morbid disease requiring
radical surgery and adjuvant therapy, which is associated with a poor prognosis. Yet …
radical surgery and adjuvant therapy, which is associated with a poor prognosis. Yet …
Ex vivo therapeutic screening of metastatic cSCC: A review of methodological considerations for clinical implementation
J Conley, JR Perry, B Ashford… - Experimental …, 2024 - Wiley Online Library
Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy
worldwide, with most deaths caused by locally advanced and metastatic disease. Treatment …
worldwide, with most deaths caused by locally advanced and metastatic disease. Treatment …
PIK your poison: the effects of combining PI3K and CDK inhibitors against metastatic cutaneous squamous cell carcinoma in vitro
Simple Summary Cutaneous squamous cell carcinoma (cSCC) is a very common skin
cancer with poor prognosis for patients with advanced disease. PI3K/AKT/mTOR and cell …
cancer with poor prognosis for patients with advanced disease. PI3K/AKT/mTOR and cell …
RNA-seq of nine canine prostate cancer cell lines reveals diverse therapeutic target signatures
EM Packeiser, L Taher, W Kong, M Ernst, J Beck… - Cancer cell …, 2022 - Springer
Background Canine prostate adenocarcinoma (PAC) and transitional cell carcinoma (TCC)
are typically characterized by metastasis and chemoresistance. Cell lines are important …
are typically characterized by metastasis and chemoresistance. Cell lines are important …
Growth and viability of cutaneous squamous cell carcinoma cell lines display different sensitivities to isoform-specific phosphoinositide 3-kinase inhibitors
V Mannella, K Boehm, S Celik, T Ali, AN Mirza… - International Journal of …, 2021 - mdpi.com
Cutaneous squamous cell carcinomas (cSCCs) account for about 20% of keratinocyte
carcinomas, the most common cancer in the UK. Therapeutic options for cSCC patients who …
carcinomas, the most common cancer in the UK. Therapeutic options for cSCC patients who …
[HTML][HTML] Protocol for the generation and automated confocal imaging of whole multi-cellular tumor spheroids
Multi-cellular tumor spheroids (MCTS) have found widespread use in pre-clinical research.
However, their complex three-dimensional structure makes immunofluorescent staining and …
However, their complex three-dimensional structure makes immunofluorescent staining and …
Investigating Cutaneous Squamous Cell Carcinoma in vitro and in vivo: Novel 3D Tools and Animal Models
M Quadri, A Marconi, SK Sandhu, A Kiss… - Frontiers in …, 2022 - frontiersin.org
Cutaneous Squamous Cell Carcinoma (cSCC) represents the second most common type of
skin cancer, which incidence is continuously increasing worldwide. Given its high frequency …
skin cancer, which incidence is continuously increasing worldwide. Given its high frequency …