SMAD7 Sustains XIAP Expression and Migration of Colorectal Carcinoma Cells
M Colella, A Iannucci, C Maresca, F Albano… - Cancers, 2024 - mdpi.com
Simple Summary Colorectal cancer (CRC) cells are characterized by high levels of SMAD7,
a protein involved in the positive control of growth and survival of cancer cells. This study …
a protein involved in the positive control of growth and survival of cancer cells. This study …
STAT3 Orchestrates Immune Dynamics in Hepatocellular Carcinoma: A Pivotal Nexus in Tumor Progression
HU SONGBAI, C YIN, G WANG, P LIU - Critical Reviews in Oncology …, 2025 - Elsevier
Hepatocellular carcinoma (HCC) presents a formidable challenge in oncology, attributed to
its association with chronic liver diseases and global prevalence. The immune …
its association with chronic liver diseases and global prevalence. The immune …
Effects of BYL-719 (alpelisib) on human breast cancer stem cells to overcome drug resistance in human breast cancer
L Yu, C Zang, Y Ye, H Liu, J Eucker - Frontiers in Pharmacology, 2024 - frontiersin.org
Introduction Breast cancer continues to be a major health concern and is currently the most
commonly diagnosed cancer worldwide. Relapse, metastasis, and therapy resistance are …
commonly diagnosed cancer worldwide. Relapse, metastasis, and therapy resistance are …
The co‐location of CD14+ APOE+ cells and MMP7+ tumour cells contributed to worse immunotherapy response in non‐small cell lung cancer
G Fan, T Xie, L Tang, L Li, X Han… - Clinical and Translational …, 2024 - Wiley Online Library
Intra‐tumour immune infiltration is a crucial determinant affecting immunotherapy response
in non‐small cell lung cancer (NSCLC). However, its phenotype and related spatial structure …
in non‐small cell lung cancer (NSCLC). However, its phenotype and related spatial structure …
A comprehensive analysis of the expression and prognostic significance of signal transducers and activators of transcription family in gastric cancer patients
Background Understanding the role of the STAT family in gastric cancer (GC) is essential for
developing targeted therapies and improving patient outcomes. However, comprehensive …
developing targeted therapies and improving patient outcomes. However, comprehensive …
Peer victimization in adolescence alters gene expression and cytokine profiles during transition to adulthood
Social adversity downregulates antiviral genes and upregulates inflammatory genes,
altering cytokine levels. We investigated how peer victimization during adolescence affects …
altering cytokine levels. We investigated how peer victimization during adolescence affects …
Integrating Bioinformatics and Artificial Intelligence Methods to identify disruptive STAT1 variants impacting Protein Stability and Function
E Kamal, LA Kaddam, M Ahmed, A Alabdulkarim - bioRxiv, 2024 - biorxiv.org
The Signal Transducer and Activator of Transcription 1 (STAT1) gene is an essential
component of the JAK-STAT signaling pathway. This pathway has a pivotal role in regulating …
component of the JAK-STAT signaling pathway. This pathway has a pivotal role in regulating …